International Journal For Multidisciplinary Research

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Formulation and Evaluation of Mouth Dissolving Loratadine Tablet using Super Disintigrants

Author(s) S.Kavya, S.Sangeetha, S.Chandra, N.Senthil Kumar
Country India
Abstract The objective of the work was design to improve palatability in orally administered products has prompted the development of formulation with improved performance and acceptability. Mouth-dispersing tablets dissolve or break down in saliva and are ingested without the use of water. Antihistamine loratadine is primarily used to treat hay fever, allergies, itchy eyes, and hives symptoms. It functions by obstructing histamine, which the body releases after an allergic reaction. The objective of the current study was to use the physical mixing approach to increase the solubility and dissolving rate using Croscarmellose sodium. From FIIR identification of drug is done and followed by physicochemical parameters. Determination of drug polymer incompatibility is by FTIR method. Loratadine MDT were prepared by using different superdisintegrants as Croscarmellose sodium, Orange peel pectine and Hibiscus mucilage by direct compression method. Only the physiochemical characterization, formulation, and in-vitro assessment of Loratadine mouthwash pills were carried out in this study. In addition to in-vitro research, in-vivo drug studies are crucial . Future in-vivo research is vital to establish the in-vitro in-vivo correlation that is required for the development of successful formulations and also long term stability studies.
Keywords Loratadine, Super disintegrants, Croscarmellose sodium, Mouth soluble tablet, In-vitro drug release.
Field Medical / Pharmacy
Published In Volume 5, Issue 6, November-December 2023
Published On 2023-12-11
Cite This Formulation and Evaluation of Mouth Dissolving Loratadine Tablet using Super Disintigrants - S.Kavya, S.Sangeetha, S.Chandra, N.Senthil Kumar - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.10349
DOI https://doi.org/10.36948/ijfmr.2023.v05i06.10349
Short DOI https://doi.org/gs8397
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