Anti-Inflammatory and Anti-oxidant Activity of Lippia Alba Leaf

S.S.V.S.Swetha; A. Supriya; B. Sirisha; B. Raja Rajeswari; K. Uma Maheswari; K. Jyothirmayee

doi:10.36948/ijfmr.2023.v05i06.10522

Anti-Inflammatory and Anti-oxidant Activity of Lippia Alba Leaf

Author(s)	S.S.V.S.Swetha, A. Supriya, B. Sirisha, B. Raja Rajeswari, K. Uma Maheswari, K. Jyothirmayee
Country	India
Abstract	Inflammation is part of the body’s defence mechanism which the immune system recognise and removes harmful and foreign stimuli and begins the healing process. The human body’s oxidation process harm DNA, protein, lipids, and other components in addition to cell membranes. As oxygen is metabolized, it produces “free radicals,” which are unstable chemicals that harm DNA and other cells by stealing electrons from other molecules. In this study, anti-inflammatory and Anti-oxidant activity of Lippia alba leaf extracts was investigated to overcome oxidation and inflammation. Lippia alba is a species of flowering plant in the Verbeanceae family having extensive properties like Anti-bacterial, Antiseptic, Anti-depressant, Anti-spasmodic, Anti-bronchitic etc,. Phytochemical Analysis of extract LEE (T1) revealed the presence of phytosterol, alkaloids, flavonoid, phenolic compounds, carbohydrates, whereas the extract of LAE (T2) revealed the presence of alkaloids, flavoniods, carbohydrates, saponins. Anti-inflammatory effect was estimated by inducing carrageenan in four group of rats i.e., control, standard, T1 and T2. Inflammation is caused by chemical mediators such as Histamine/Serotinin, Bradykinin, Prostaglandin, Lysosomes, Inhibition of carrageenan induced inflammation by leaf extracts could be due to inhibition of cyclooxygenase and prostaglandin synthesis. The LEE extract of Lippia alba leaf has shown significant anti-inflammatory activity. Anti-oxidant activity was estimated by mixing the sample with H2SO4, Ammonium molybdate , Na3PO4 and incubated at 95°C for 10min and absorbance was measured at 695 nm .The LEE extract of Lippia alba leaf shown more anti-oxidant activity than LAE. This study has shown that LEE of Lippia alba has shown significant Anti-inflammatory and Anti-oxidant activity. These studies justify the traditional use of plants in some inflammatory and oxidant condition.
Keywords	Anti-inflammation, Anti-oxidant, Lippia alba, Bradykinin, Prostaglandin.
Field	Medical / Pharmacy
Published In	Volume 5, Issue 6, November-December 2023
Published On	2023-12-20
Cite This	Anti-Inflammatory and Anti-oxidant Activity of Lippia Alba Leaf - S.S.V.S.Swetha, A. Supriya, B. Sirisha, B. Raja Rajeswari, K. Uma Maheswari, K. Jyothirmayee - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.10522
DOI	https://doi.org/10.36948/ijfmr.2023.v05i06.10522
Short DOI	https://doi.org/gs98vq

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Anti-Inflammatory and Anti-oxidant Activity of Lippia Alba Leaf

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