International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 6 Issue 6 November-December 2024 Submit your research before last 3 days of December to publish your research paper in the issue of November-December.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 6 Issue 6
November-December 2024

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Plumbagin's molecular docking studies as a possible target for the SARS-CoV-2 spike receptor protein

Author(s) Murugesan Raman, Girija Shanmugam, Ashokkumar Jayavel
Country India
Abstract Around the end of 2019, reports of unusual cases of pneumonia with specific symptoms started to arrive in Wuhan, China. Within a few weeks, the atypical pneumonia spread throughout China, and a few months after that, it became a global pandemic. The etiological agent of that pandemic, which is officially known as COVID-19, is Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In an attempt to find an efficient therapy to either fight the spread of COVID-19 or to cure infected people from its tissue damage, researchers around the world have been studying several plants, herbs, and natural products. Abundant studies have revealed that organic compounds can be very operative in averting virus-mediated infection. The purpose of this study was to accomplish molecular docking studies among plant-derived naphthoquinone (Plumbagin) and spike receptor (THR304) proteins of coronavirus. MGL virtual screening tool and Biovia Discovery Studio were utilized in the current molecular docking investigations. Outcomes of docking studies exposed that selected organic compounds have interacted with targeted spike receptor protein with binding energies in the range of -4.0 to -9.5 kcal, which means the binding energy of the target and ligand is -5.78. In summary, plumbagin seems to be a more effective primary protease inhibitor than the other chosen ligands for deactivating the SARS-Coronavirus.
Keywords SARS-CoV-2; Plumbagin; Molecular docking.
Field Biology
Published In Volume 5, Issue 6, November-December 2023
Published On 2023-12-20
Cite This Plumbagin's molecular docking studies as a possible target for the SARS-CoV-2 spike receptor protein - Murugesan Raman, Girija Shanmugam, Ashokkumar Jayavel - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.10771
DOI https://doi.org/10.36948/ijfmr.2023.v05i06.10771
Short DOI https://doi.org/gs98tj
View / Download PDF File

Share this



E-ISSN 2582-2160
CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJFMR DOI prefix is
10.36948/ijfmr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 6 Isu 6Cover Page Vol 6 Isu 5Cover Page Vol 6 Isu 4

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJFMR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9898-5948-55 editor@ijfmr.com