International Journal For Multidisciplinary Research

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A Use of Medicinal Plant with Transfersome as a Vesicular Carrier that Increase the Permeation

Author(s) Vaibhavkumar Bapu Bhagwat, Mayuri Jagtap, Onkar B. Doke, Priyanka K. Shinde
Country India
Abstract The goal of the study was to create Transfersomes, a unique vesicular carrier with improved anti-Inflammatory effects by lowering the gastrointestinal toxicity linked to oral administration. Phospholipids, extract from medicinal plants, and transfersomes made by Thin Film Hydration Techniques employing surfactants are some of the components of medicinal plants that are used in varying proportions. Particle size, entrapment efficiency, zeta potential, in vitro drug release, and transmission electron microscopy were assessed for the prepared Transfersomes. Using Fourier transform infrared spectroscopy [FT-IR], the compatibility between the medicinal plant extract and the excipients was assessed, and they were found to be compatible. Vesicle size was observed in the batch Transfersomes that were optimized. The best batch formulations of Transfersomes were mixed with polymer and tested for drug content, pH, spreadability, and in vitro penetration against commercial products. Compared to branded formulation, the deformed vesicle formed formulation performs better when combined with edge activator. Transfersome formulations containing medicinal plant extract have been found to offer a higher permeation rate than commercial formulations, based on parameters such as extract of medicinal plant release that were analyzed.
Keywords Transfersomes, Deformable and Ultra Vesicles, Medicinal Plant, Edge Activators, phosphatidylcholine, Stratum Corneum.
Field Medical / Pharmacy
Published In Volume 5, Issue 6, November-December 2023
Published On 2023-12-28
Cite This A Use of Medicinal Plant with Transfersome as a Vesicular Carrier that Increase the Permeation - Vaibhavkumar Bapu Bhagwat, Mayuri Jagtap, Onkar B. Doke, Priyanka K. Shinde - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.11241
DOI https://doi.org/10.36948/ijfmr.2023.v05i06.11241
Short DOI https://doi.org/gtbthm
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