Formulation and Characterization of Blend Microspheres of Anti Diabetic Drug Glimepiride

Ashif Ali Mansoori

doi:10.36948/ijfmr.2023.v05i06.11381

Formulation and Characterization of Blend Microspheres of Anti Diabetic Drug Glimepiride

Author(s)	Ashif Ali Mansoori
Country	India
Abstract	The objective of the present investigation was to prepare polymeric blend microspheres of glimepiride for improving its half-life using chitosan and gelatin as the two polymers for preparing the blend. The blend microspheres of chitosan and gelatin were prepared by using different ratios of both the polymers as well as cross-linking agent, glutaraldehyde (GA), by emulsion cross-linking method. The optimum formulation was one which exhibited the lowest particles size and it was used to load glimepiride (20% by weight) of the polymers. The glimepiride loaded blend microspheres were evaluated for yield, drug polymer interaction, entrapment efficiency, surface study and in vitro release. The particle size of the blend microspheres was found to be in the range of 126.8 µm to 371.3 µm. The lowest particle size (126.8 ± 6.11 µm) was obtained in AF5 containing 50% of gelatin and 50% of chitosan. The FTIR spectra of the physical mixture of glimepiride, gelatin and chitosan displayed all the characteristic peaks of glimepiride, thus indicating that no incompatibility was present between the drug and the polymer. The SEM image of the drug loaded blend microsphere revealed spherical particles of irregular size with smooth surface. The average particles size of the glimepiride loaded blend microspheres was obtained to be 131.4 ± 9.7 µm with a yield of 91.6% by weight of the drug and polymers used for formulation of the microspheres. It was found that 82.4 ± 6.8% of glimepiride was found to be entrapped in the particles. The results of the in vitro release studies of the glimepiride loaded blend microsphere revealed that 71.49 ± 0.74 % glimepiride was released from the particles at the end of 12th hour of study.
Keywords	blendmicrospheres,glimepiride,polymer,gelatin,chitosan
Field	Medical / Pharmacy
Published In	Volume 5, Issue 6, November-December 2023
Published On	2023-12-31
Cite This	Formulation and Characterization of Blend Microspheres of Anti Diabetic Drug Glimepiride - Ashif Ali Mansoori - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.11381
DOI	https://doi.org/10.36948/ijfmr.2023.v05i06.11381
Short DOI	https://doi.org/gtbtdq

View / Download PDF File

E-ISSN 2582-2160

doi

CrossRef DOI is assigned to each research paper published in our journal.

IJFMR DOI prefix is
10.36948/ijfmr

Downloads

Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 6 Isu 6 Cover Page Vol 6 Isu 5 Cover Page Vol 6 Isu 4

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA

About IJFMR Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us		+91-9898-5948-55	editor@ijfmr.com

International Journal For Multidisciplinary Research

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Formulation and Characterization of Blend Microspheres of Anti Diabetic Drug Glimepiride

Share this