Green Synthesis of Silver Nanoparticles from Bark Extract to Detect Anti Ulcer Activity in Swiss Albino Rats

Author(s)	Kalpana p Ghoshal, Ajay Ghatole
Country	India
Abstract	The anti-ulcer activity of Butea monosperma silver nanoparticles (SNBM) was estimated in Swiss albino rats using ulcers caused by histamine, drugs, and ethanol. The effects of the SNBM at the doses of 300 and 550 mg/kg per os (p.o.) were compared with those of the reference pharmaceuticals, famotidine (35 mg/kg b.w.), and revealed substantial safeguards against ulcers generated by indomethacin and histamine. Additionally, the extract demonstrated excellent resistance against stomach ulcers brought on by ethanol. In addition, in ethanol-induced stomach ulceration, SNBM drastically lowered the spike in lipid peroxide level [(Thiobarbituric acid reactive substances (TBARS)] and restored the altered glutathione level. According to the study, SNBM demonstrates anti-ulcer efficacy by enhancing the gastric mucosa's antioxidant capacity and minimizing mucosal damage.
Keywords	Silver Nanoparticles; Butea Monosperma; Anti-Ulcer Activity.
Field	Biology > Agriculture / Botany
Published In	Volume 6, Issue 1, January-February 2024
Published On	2024-02-02
Cite This	Green Synthesis of Silver Nanoparticles from Bark Extract to Detect Anti Ulcer Activity in Swiss Albino Rats - Kalpana p Ghoshal, Ajay Ghatole - IJFMR Volume 6, Issue 1, January-February 2024. DOI 10.36948/ijfmr.2024.v06i01.12392
DOI	https://doi.org/10.36948/ijfmr.2024.v06i01.12392
Short DOI	https://doi.org/gtgs67

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