Synthesis, Characterization and Biological Evaluation of 6-(5-Chloro-8-Hydroxynapthalene-2-yl)-4(4-Hydroxyphenyl)-4-5-Dihydroxypyrimidin-2(1h)-One

Author(s)	V.M. Sherekar, N.S. Padole, K.P. Kakade
Country	India
Abstract	1-(4- Chloro -1-hydroxynaphthalen-2-yl)-ethanone was prepared by refluxing 4-chloronaphthalen-1-ol with glacial acetic acid in presence of fused ZnCl2. From this synthesized compound we prepared 1-(4- Chloro -1- hydroxynaphthalen-2-yl)-3-(4-hydroxy phenyl)-prop-2-en-1-one from condensing 1-(4- Chloro -1-hydroxynaphthalen-2- yl)-ethenone, The final product 6-(5-chloro-8-hydroxynapthalene-2-yl)-4(4-hydroxyphenyl)-4-5-dihydroxypyrimidin-2(1h)-one, by condensation in presence of urea and concentrated HCl in DMF. The compounds thus synthesized have been characterized by physical and spectral data. This titled synthesized compound was screened for antimicrobial study and are found to possess excellent antimicrobial activities due to presence of chlorine as a substituent on main nucleus.
Keywords	Antimicrobial activities, cold NH4OH solution, concentrated HCl in DMF
Field	Chemistry
Published In	Volume 4, Issue 6, November-December 2022
Published On	2022-12-28
Cite This	Synthesis, Characterization and Biological Evaluation of 6-(5-Chloro-8-Hydroxynapthalene-2-yl)-4(4-Hydroxyphenyl)-4-5-Dihydroxypyrimidin-2(1h)-One - V.M. Sherekar, N.S. Padole, K.P. Kakade - IJFMR Volume 4, Issue 6, November-December 2022. DOI 10.36948/ijfmr.2022.v04i06.1240
DOI	https://doi.org/10.36948/ijfmr.2022.v04i06.1240
Short DOI	https://doi.org/grkbw5

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