Analysis of Genetic Spectrum in Polycystic Ovary Syndrome- A Review

Susanta Sadhukhan; Nirvika Paul; Shreemoyee Palmal; Rituparna Patra; Atanu Panja; Moumita Malik; Krishnendu Ghosh; Arup Kumar Pattanayak

doi:10.36948/ijfmr.2024.v06i01.13439

Analysis of Genetic Spectrum in Polycystic Ovary Syndrome- A Review

Author(s)	Susanta Sadhukhan, Nirvika Paul, Shreemoyee Palmal, Rituparna Patra, Atanu Panja, Moumita Malik, Krishnendu Ghosh, Arup Kumar Pattanayak
Country	India
Abstract	Polycystic ovary syndrome (PCOS) is increase in an alarming rate since 1935. According to WHO the prevalence rate of PCOS is 3.4% worldwide. Hyperandrogenism, chronic anovulation, small cysts and increase in size of the ovary are the most common diagnostic feature for PCOS. Beside the environmental factors PCOS is highly associated with genetic back up of an individual. So, Different genetic pathways like steroid hormone synthesis , ovarian and adrenal steroidogenesis, gonadotropin action, insulin action and secretion, energy homeostasis , chronic inflammation pathways plays most important role in PCOS progression. Furthermore several report suggested that, some other genes like plasminogen activator inhibitor-1 (PAI-1), HSD3B2 , 17α-hydroxysteroid dehydrogenases, dopamine receptor, IGF107, aldosterone synthetase , paraoxonase, glycogen synthetase, resistin, apoprotein E are also involved in PCOS progression. From different case report it is established that epilepsy and diabetes condition are the two main regulators for PCOS progression. Whereas, epigenetic mechanism is also involved in the pathogenesis of PCOS. Some of the therapeutics is also available for treatment of PCOS but not ensure proper cure. Long-term treatment for PCOS, increases the risk of developing metabolic and cardiovascular abnormalities. So the main aim of this review is to reveal all aspects of genetics mechanism related to PCOS for better understanding of the disease. As well as established a profile of regulatory marker gene for early diagnosis and to develop a better treatment protocol.
Keywords	PCOS, IGF107, Androgen receptor gene, Serum Sex Hormone-Binding Globulin (SHBG), Follistatin coding gene.
Field	Biology > Genetics / Molecular
Published In	Volume 6, Issue 1, January-February 2024
Published On	2024-02-19
Cite This	Analysis of Genetic Spectrum in Polycystic Ovary Syndrome- A Review - Susanta Sadhukhan, Nirvika Paul, Shreemoyee Palmal, Rituparna Patra, Atanu Panja, Moumita Malik, Krishnendu Ghosh, Arup Kumar Pattanayak - IJFMR Volume 6, Issue 1, January-February 2024. DOI 10.36948/ijfmr.2024.v06i01.13439
DOI	https://doi.org/10.36948/ijfmr.2024.v06i01.13439
Short DOI	https://doi.org/gtjt2m

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Analysis of Genetic Spectrum in Polycystic Ovary Syndrome- A Review

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