International Journal For Multidisciplinary Research

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In-Vitro and In-Silico Analysis of Antimicrobial Efficacy in Annona Muricata Leaf Extracts

Author(s) Shivali U Shetty, Sanjeev Rai B, Beena Antony, Animik Ray, Shruthi B, Sanjeev Rai B
Country India
Abstract Annona muricata and Annona reticulata, known for their traditional medicinal uses and antimicrobial properties, were investigated for their potential antibacterial effects. Extracts from fresh leaves were tested for antimicrobial activity, revealing that Annona muricata exhibited superior antibacterial properties compared to Annona reticulata, especially against E. coli strains. In silico analysis focused on 46 phytochemicals extracted from Annona muricata, which were docked with key bacterial proteins, including Gyrase, the 30S and 50S ribosomal subunits, Topoisomerase IV, and penicillin-binding protein. Notably, phytochemicals such as Quercetin 3–O-rutinoside (Rutin), Quercetin 3-O-neohesperidoside, Quercetin 3-O-glucoside (Isoquercetin), Luteolin 3´7-di-O-glucoside, and Homoorientin demonstrated strong docking scores and confidence score, indicating potential interactions that could lead to bacterial destruction. These findings suggest that certain phytochemicals of Annona muricata is a promising candidate for antibiotic development, opening avenues for further exploration in combating bacterial infections.
Keywords Antibacterial Effects, Phytochemicals, Anonna muricata, Molecular Docking
Field Biology
Published In Volume 6, Issue 1, January-February 2024
Published On 2024-02-18
Cite This In-Vitro and In-Silico Analysis of Antimicrobial Efficacy in Annona Muricata Leaf Extracts - Shivali U Shetty, Sanjeev Rai B, Beena Antony, Animik Ray, Shruthi B, Sanjeev Rai B - IJFMR Volume 6, Issue 1, January-February 2024. DOI 10.36948/ijfmr.2024.v06i01.13628
DOI https://doi.org/10.36948/ijfmr.2024.v06i01.13628
Short DOI https://doi.org/gtjtxx
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