International Journal For Multidisciplinary Research

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Antimicrobial Activity of Four Different Commercially Available Antibiotics against Selected Bacteria Isolated from Urine Samples of UTI Patients

Author(s) Dharitri Priyadarsini, Kumudinee Kumari Mahto, Lipika Das, Srotaswinee Biswal
Country India
Abstract More than thirty percent of the global population suffers from urinary tract infections. While many infections are currently treated empirically, appropriate standards for the prudent use of antibiotics should be concentrated on preventing the emergence of bacterial resistance and the elevated risk of infections that are challenging to treat. The article includes and discusses pertinent information about risk factors, severity levels, and the proper microbiological interpretation of pathogens. Research was done to compare the in vitro antibacterial activity of commercial antibiotics that are frequently used to treat urinary tract infections (UTIs) to clinical isolates that were obtained from urine samples of patients who were suffering from UTIs. A total of 5 isolates were identified as Escherichia coli, Staphylococcus aureus, Salmonella typhi, Staphylococcus epidermidis and Pseudomonas aeruginosa, following different morphological, physiological and biochemical tests. Antibiotic sensitivity of four commercial antibiotics viz., cefpodoxime, cefuroxime, amoxicillin, and ciprofloxacin was screened by disc diffusion assay. Among the four antibiotic discs tested 40% of isolates were resistant to cefuroxime followed by 20% to cefpodoxime, amoxicillin and ciprofloxacin. 40% of the isolates were found to be resistant to multiple antibiotics and termed as multi-drug resistant (MDR) isolates. Cefpodoxime shows smallest zone of inhibition against Staphylococcus epidermidis and Staphylococcus aureus of about 7 mm and 8 mm, respectively. Hence, further research should be carried out to identify the active biomolecules or Phyto-molecules from the plants and determine the effects of them in vitro as well as in vivo.
Keywords Escherichia coli, Staphylococcus aureus, Salmonella typhi, Staphylococcus epidermidis, Pseudomonas aeruginosa, multi-drug resistant, cefpodoxime, cefuroxime, amoxicillin, ciprofloxacin, urinary tract infections, antibacterial activity, colony morphology.
Field Biology > Bio + Chemistry
Published In Volume 6, Issue 1, January-February 2024
Published On 2024-02-15
Cite This Antimicrobial Activity of Four Different Commercially Available Antibiotics against Selected Bacteria Isolated from Urine Samples of UTI Patients - Dharitri Priyadarsini, Kumudinee Kumari Mahto, Lipika Das, Srotaswinee Biswal - IJFMR Volume 6, Issue 1, January-February 2024. DOI 10.36948/ijfmr.2024.v06i01.13657
DOI https://doi.org/10.36948/ijfmr.2024.v06i01.13657
Short DOI https://doi.org/gthqkw
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