International Journal For Multidisciplinary Research

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Nyctanthes Arbor-tristis: Biological Activites

Author(s) Aradhana Singh, Nidhi Gupta, Shweta Singh, Akanksha Awasthi
Country India
Abstract Rheumatism and inflammatory illnesses have long been treated with NAT. Using Freund's adjuvant-induced arthritic rat model, current study assesses antiarthritic potential of NAT. For a total of twenty days in a row, treatments with methanolic, ethyl acetate, and n-hexane extracts were administered. The assessment of arthritic development was done using water displacement plethysmometry and macroscopic arthritic grading. The study examined hematological and biochemical data and processed ankle joints for histological assessment. The ingredients were identified by GC-MS analysis and qualitative phytochemical examination. The infiltration of inflammatory cells, bone degradation, paw edema, pannus development, and arthritic scoring were all inhibited by NAT extracts. The plant extracts restored hemoglobin (Hb) content and red blood cell (RBC) counts to almost normal levels while also improving total leukocyte and platelet counts. As assessed by levels of alanine aminotransferase (ALT), creatinine, urea, aspartate aminotransferase (AST). Hepatotoxicity and nephrotoxicity, the extracts were deemed safe. Ethyl acetate extract caused best prevention of paw edema, according to comparative analysis of data. Terpenes, terpenoids, iridoid glycosides and fatty acids are three main classes into which contents of ethyl acetate extract can be divided. According to the current investigation, ethyl acetate extract had highest inhibitory action and NAT improved experimental rheumatoid arthritis.
Keywords hepatotoxicity, nephrotoxicity, aminotransferase and Nyctanthes arbor-tristis,
Field Medical / Pharmacy
Published In Volume 6, Issue 2, March-April 2024
Published On 2024-03-06
Cite This Nyctanthes Arbor-tristis: Biological Activites - Aradhana Singh, Nidhi Gupta, Shweta Singh, Akanksha Awasthi - IJFMR Volume 6, Issue 2, March-April 2024. DOI 10.36948/ijfmr.2024.v06i02.14579
DOI https://doi.org/10.36948/ijfmr.2024.v06i02.14579
Short DOI https://doi.org/gtmbg2
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