Use of Microbial L-asparaginase in Cancer Treatment -A Detail Review

Author(s)	Tank Shivangi, Saloni Gautam
Country	India
Abstract	Abstract The exceptional anticancer effects of l-asparaginases, which hydrolyze plasma l-asparagine and l-glutamine, have drew a lot of interest in recent years. This enzyme is effective against acute lymphoblastic leukemia (ALL) and lymphosarcoma, as well as ALL in children, neoplasia, and various other cancer .The l-asparaginase anticancer application technique has achieved amazing advances in modern oncology by depleting plasma l-asparagine to suppress cancer cell development, notably in youngsters. As bacterial alternative enzyme sources for anticancer therapy, high levels of l-asparaginase enzyme production by Escherichia coli, Erwinia species, Streptomyces, and Bacillus subtilis species are very desirable. Purification of L-asparaginase by Ammonium Sulphate precipitation and various chromatographic technique methods, and improvement of enzyme purity by dialysis confirmation of molecular weight with SDS page.
Keywords	Keywords: L-asparaginases - Cancer treatment-Immune suppression - Food industry
Field	Biology > Bio + Chemistry
Published In	Volume 6, Issue 2, March-April 2024
Published On	2024-04-12
Cite This	Use of Microbial L-asparaginase in Cancer Treatment -A Detail Review - Tank Shivangi, Saloni Gautam - IJFMR Volume 6, Issue 2, March-April 2024. DOI 10.36948/ijfmr.2024.v06i02.16620
DOI	https://doi.org/10.36948/ijfmr.2024.v06i02.16620
Short DOI	https://doi.org/gtqxzk

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