Development of Uv-visible and Hplc Analytical Methods for Quantitative Analysis of Antiulcer Drugs in Dosage Forms

Deepak Goel; Himanchal Sharma; Ashish kumar verma

doi:10.36948/ijfmr.2024.v06i04.16954

Development of Uv-visible and Hplc Analytical Methods for Quantitative Analysis of Antiulcer Drugs in Dosage Forms

Author(s)	Deepak Goel, Himanchal Sharma, Ashish kumar verma
Country	india
Abstract	Precise measurement of active pharmaceutical ingredients (APIs) in dosage forms is crucial in the pharmaceutical business to guarantee the quality, effectiveness, and safety of the product. This research is focused on creating and confirming analytical techniques for accurately measuring the amount of antiulcer medicines in different types of medication. The measurement of antiulcer medicines in their respective formulations was carried out using two analytical techniques: UV-Visible spectroscopy and High-Performance Liquid Chromatography (HPLC). UV-Visible spectroscopy is a straightforward and cost-effective method that allows for quick examination. It is particularly useful for regular quality control applications. HPLC, in contrast, offers exceptional sensitivity, specificity, and precision, facilitating the isolation and measurement of many constituents in complex matrices. The technique development procedure included optimizing experimental parameters, including solvent systems, detection wavelengths, column types, mobile phase composition, and flow rates. The reliability and robustness of the suggested procedures were ensured by validation studies done in accordance with ICH recommendations. The adequacy of the procedures for their intended purpose was assessed by evaluating parameters such as linearity, precision, accuracy, specificity, and robustness. The UV-Visible and HPLC techniques that were developed showed exceptional linearity over the examined concentration range, with correlation values (R²) above 0.99. The precision experiments showed low relative standard deviations (RSDs), suggesting excellent repeatability and moderate accuracy. The accuracy checks demonstrated that the recovery values were within acceptable ranges, therefore verifying the dependability of the methodologies used for quantitative analysis.
Field	Medical / Pharmacy
Published In	Volume 6, Issue 4, July-August 2024
Published On	2024-08-01
Cite This	Development of Uv-visible and Hplc Analytical Methods for Quantitative Analysis of Antiulcer Drugs in Dosage Forms - Deepak Goel, Himanchal Sharma, Ashish kumar verma - IJFMR Volume 6, Issue 4, July-August 2024. DOI 10.36948/ijfmr.2024.v06i04.16954
DOI	https://doi.org/10.36948/ijfmr.2024.v06i04.16954
Short DOI	https://doi.org/gt557b

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Development of Uv-visible and Hplc Analytical Methods for Quantitative Analysis of Antiulcer Drugs in Dosage Forms

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