International Journal For Multidisciplinary Research

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Novel Antimicrobial Peptides Derived from Urease-2 of Jack Beans for Treatment of Indian Priority Pathogens

Author(s) Mugdha Belwalkar, Aditi Thakkar, Varsha Shukla, Anushree Lokur
Country India
Abstract Antimicrobial peptides (AMPs) are short-chain amino acid sequences that play crucial roles in the host immune response. Canavalia ensiformis, commonly known as the jack bean, has long been recognized as a valuable protein source for biochemical investigations. Jaburetox, a jack bean protein, is a potent antifungal agent and biopesticide. However, it also exhibits neurotoxic effects. Therefore, it cannot be used as a potential drug for the treatment of bacterial diseases. This study focused on identifying small and nontoxic antibacterial regions within Jack Bean Urease 2, a specific isoform of Jack Bean Urease. The antimicrobial peptides derived from this enzyme may show inhibitory effects against pathogens such as Acinetobacter baumannii ATCC 19606, Klebsiella pneumoniae ATCC700603, Pseudomonas aeruginosa ATCC27853, Salmonella typhimurium ATCC14028, Escherichia coli ATCC25922, Enterococcus faecalis ATCC 29212, and Staphylococcus aureus ATCC 25923. Comprehensive assessments of physicochemical, medicinal chemistry, and ADMET properties were conducted to identify the most suitable candidates for in vivo testing against the Indian Priority Pathogen List of Pathogens.
Keywords Antimicrobial Resistance, Antimicrobial Peptides, In silico approach, Pharmacokinetic
Field Biology > Bio + Chemistry
Published In Volume 6, Issue 2, March-April 2024
Published On 2024-04-17
Cite This Novel Antimicrobial Peptides Derived from Urease-2 of Jack Beans for Treatment of Indian Priority Pathogens - Mugdha Belwalkar, Aditi Thakkar, Varsha Shukla, Anushree Lokur - IJFMR Volume 6, Issue 2, March-April 2024. DOI 10.36948/ijfmr.2024.v06i02.17551
DOI https://doi.org/10.36948/ijfmr.2024.v06i02.17551
Short DOI https://doi.org/gtrfk8
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