Formulation of Different Polymer Coated Spherules from Granules

Author(s)	Aarti Vitthal Mogal, Dhawale Tejaswini
Country	India
Abstract	A novel spheronisation technique is reported here for forming spherules from granules using FDA approved excipients and common pharmaceutical unit operations. The aspirin is used as a model drug to check stability during the process. For that, spherules are prepared by “bed coating during sliding” (BCDS) of granules. Spherules with two size range (sieve no 20 and 30) are compared. These spherules are further coated with polymers to show the versatility of the process. flow property determination.. Angle of Repose sand packing parameters appeared excellent. Different polymer coating gives different release profile as per the properties of the polymer. However, the drug content is lower for 30 as compared to 20 while drug release profile appears similar. This is a robust and versatile platform delivery system for developing advanced drug delivery systems (ADDS).
Keywords	Spherules, Granulation, Spheronization, Bed coating during sliding(BCDS), Advanced drug delivery system(ADDS), fluidised bed drying(FBD).
Field	Medical / Pharmacy
Published In	Volume 5, Issue 2, March-April 2023
Published On	2023-03-08
Cite This	Formulation of Different Polymer Coated Spherules from Granules - Aarti Vitthal Mogal, Dhawale Tejaswini - IJFMR Volume 5, Issue 2, March-April 2023. DOI 10.36948/ijfmr.2023.v05i02.1796
DOI	https://doi.org/10.36948/ijfmr.2023.v05i02.1796
Short DOI	https://doi.org/grwssf

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