International Journal For Multidisciplinary Research

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Utility of Dexmedetomidine in Paediatric Cardiac Surgery: a Systematic Review and Meta-analysis

Author(s) Vishnu Datt, Diksha Datt, Anumeha V, Garima Sangwan, Karan Juneja, Sneha Satya, Priyanka
Country India
Abstract Dexmedetomidine is a selector α 2-agonist that provides sedation with sparing respiratory depression, anxiolysis, and analgesic adjunct with opioids and benzodiazepines sparing effects, prolongs the duration of regional anesthesia and allows early tracheal extubation after pediatric cardiac surgery.[1,2,3 ] Recently, dexmedetomidine has been established as a cardioprotective agent in adult cardiac surgical patients. Some trials show significantly lower myocardial injury markers like interleukin-6 (IL-6) levels, cardiac troponin I (cTnI), and creatinine kinase-myocardial band (CK-MB), after cardiac surgery in the dexmedetomidine group.[ ] The majority of published studies have suggested that dexmedetomidine is a seemingly efficacious agent protecting against cardiac injury during CPB.[6] Its administration lowers mechanical ventilation period, ICU stay, and length of hospital stay after pediatric cardiac surgery. In addition, it is effective against postoperative shivering, refractory JET rhythm and Tet spells, and acute kidney injury (AKI) in cyanotic pediatric patients undergoing corrective surgery. However, studies on its application in pediatric heart surgery using cardiopulmonary bypass (CPB) remain limited. This systematic review aimed to provide information on the utility of dexmedetomidine in patients undergoing pediatric cardiac surgery using CPB: hemodynamic stability, cardioprotective, renal protection, neuroprotective effects, control of refractory JET, and Tet spells, and the early and late outcome.
Keywords Dexmedetomidine, paediatric cardiac surgery, hemodynamic stability, perioperative sedation, early extubation, Tet spells, JET, organ protection, AKI, mechanical ventilation duration
Field Medical / Pharmacy
Published In Volume 6, Issue 3, May-June 2024
Published On 2024-05-04
Cite This Utility of Dexmedetomidine in Paediatric Cardiac Surgery: a Systematic Review and Meta-analysis - Vishnu Datt, Diksha Datt, Anumeha V, Garima Sangwan, Karan Juneja, Sneha Satya, Priyanka - IJFMR Volume 6, Issue 3, May-June 2024. DOI 10.36948/ijfmr.2024.v06i03.19314
DOI https://doi.org/10.36948/ijfmr.2024.v06i03.19314
Short DOI https://doi.org/gttbhd
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