International Journal For Multidisciplinary Research

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Action of Areal Parts of Solanum Torvum on Allergic Action and Mast Cell Stabilization on Laboratory Animals

Author(s) SINDHU S, BHARATH KUMAR D R, SAHANA H C
Country India
Abstract Solanum torvum (Solanaceae) Areal parts of plant has been extensively in iIndian traditional medicine for the treatment of asthma and bronchitis. The present study was designed to evaluate the anti-allergic activity of hydro- alchoholic extract of Solanum torvum. Areal parts of plant in experimental animals. The ant allergic activity of the extract was evaluated on compound 48/80 induced mast cell degranulation in rat mesentery and milk induced leukocytes and eosinophilia in mice. Treatment of HAST (300 and 600 mg/kg p.o.) showed significant (p<0.001) protection against compound 48/80 (1 mg/kg s.c.)-induced mast cell degranulation mesenteric pans. The hydro alcoholic extract of Solanum torvum Areal parts of plant inhibited milk induced model Pre-treatment of HAST (200 and 400 mg/kg, p.o.) to group of mice exhibited significantly (p<0.001;) reduced the milk (4 ml/kg s.c.)-induced elevated levels of blood total leukocyte and eosinophils counts. The observed beneficial effect of title plant may be attributed to reported bioactive compounds and their synergistic outcome.
Keywords Solanum torvum, Anti-allergic, Leukocytes, Eosinophils, Mast cells, Compound 48/80.
Field Medical / Pharmacy
Published In Volume 6, Issue 3, May-June 2024
Published On 2024-05-29
Cite This Action of Areal Parts of Solanum Torvum on Allergic Action and Mast Cell Stabilization on Laboratory Animals - SINDHU S, BHARATH KUMAR D R, SAHANA H C - IJFMR Volume 6, Issue 3, May-June 2024. DOI 10.36948/ijfmr.2024.v06i03.21491
DOI https://doi.org/10.36948/ijfmr.2024.v06i03.21491
Short DOI https://doi.org/gtw6rc
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