International Journal For Multidisciplinary Research

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Ancistrocline: A Naphthyl Isoquinoline Alkaloid from the Leaves of Ancistrocladus Heyneanus; Exhibits Anticancer Property Against PLC/PRF/5 Hepatoma Cells

Author(s) Anil Karn, Anuradha Pandey Dubey, Sudhakar More, Madhuri Sharon
Country India
Abstract From the leaves of an Indian species of Ancistrocladus heyneanus, crude extract of mixed Naphthyl Isoquinoline alkaloids were tested against cytotoxicity and anti-cancer activity using MDCK 2 -cells and PLC/PRF/5 -cells. It showed >50% viability of MDCK 2 -cells, at all tried concentrations, showing it to be non-toxic to normal cells. Whereas, response to the viability of PLC/PRF/5 -cells at all concentrations of alkaloid exhibited a decrease in viability with increase in concentration, suggesting anti-cancer property of alkaloids. Since extract from leaves was a mixture of alkaloids, it was thought desirable to separate the alkaloids to see which alkaloid had anti-cancer property. We report anti-cancer property of separated Ancistrocline alkaloid. The alkaloids were separated using TLC, which showed 3-bands. Only middle band of the TLC bands, that has a molecular weight of 421 (as detected by LC/MS) and identified as Ancistrocline by NMR, has exhibited anti-cancer activity against PLC/PRF/5 -cells and was non-cytotoxic against MDCK 2 -cells
Keywords Ancistrocladus heyneanus, Naphthyl Isoquinoline Alkaloids, Ancistrocline, MDCK 2 -cells, PLC/PRF/5 -cells, Anti-cancer
Field Biology > Bio + Chemistry
Published In Volume 6, Issue 3, May-June 2024
Published On 2024-06-08
Cite This Ancistrocline: A Naphthyl Isoquinoline Alkaloid from the Leaves of Ancistrocladus Heyneanus; Exhibits Anticancer Property Against PLC/PRF/5 Hepatoma Cells - Anil Karn, Anuradha Pandey Dubey, Sudhakar More, Madhuri Sharon - IJFMR Volume 6, Issue 3, May-June 2024. DOI 10.36948/ijfmr.2024.v06i03.22144
DOI https://doi.org/10.36948/ijfmr.2024.v06i03.22144
Short DOI https://doi.org/gtzjnj
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