In Silico Exploration of Hsp90 as a Therapeutic Target in Skin Cancer: Computational Perspectives

ISHAN JOSHI; AJIJUR REHMAN

doi:10.36948/ijfmr.2024.v06i03.22192

In Silico Exploration of Hsp90 as a Therapeutic Target in Skin Cancer: Computational Perspectives

Author(s)	ISHAN JOSHI, AJIJUR REHMAN
Country	India
Abstract	Skin cancer is a serious global health concern that is on the rise and for which there are few viable treatments when the disease reaches later stages. Heat shock protein 90 (Hsp90) has emerged as a critical molecular chaperone in the stability and function of multiple client proteins, including those associated to skin cancer, that are implicated in the start and spread of cancer. An overview of Hsp90's involvement in the etiology of skin cancer is provided in this abstract, along with discussion of the therapeutic potential of targeting Hsp90 as a therapeutic approach. Preclinical research using small molecule inhibitors and molecular methods has demonstrated encouraging anti-cancer effects by disrupting Hsp90-client protein interactions. Skin cancer cells die as a result of this, as well as the disruption of carcinogenic signaling pathways. Hsp90 inhibitors may also be used in combination therapy in clinical settings, as evidenced by their synergistic benefits with conventional therapies. However, because of challenges such drug resistance and off-target consequences, further study is needed to improve Hsp90-targeted therapies for skin cancer. All things considered, concentrating on Hsp90 provides a feasible route for the development of innovative therapeutic approaches to combat skin cancer and improve patient outcomes. While less common in people of color than in light-skinned Caucasians, skin cancer is frequently linked to higher rates of morbidity and death. among order to increase the chance of early tumor diagnosis, it is imperative that doctors learn about skin cancer among people of color. Squamous cell carcinoma is more common in ethnic groups with darker skin; melanoma and squamous cell carcinoma typically develop on non-sun-exposed locations; and ultraviolet light is not a significant etiologic factor for skin cancer, with the exception of basal cell carcinoma.
Keywords	Hsp90's, Skin Cancer, Therapeutic, Chaperone
Field	Biology > Genetics / Molecular
Published In	Volume 6, Issue 3, May-June 2024
Published On	2024-06-14
Cite This	In Silico Exploration of Hsp90 as a Therapeutic Target in Skin Cancer: Computational Perspectives - ISHAN JOSHI, AJIJUR REHMAN - IJFMR Volume 6, Issue 3, May-June 2024. DOI 10.36948/ijfmr.2024.v06i03.22192
DOI	https://doi.org/10.36948/ijfmr.2024.v06i03.22192
Short DOI	https://doi.org/gt2cbj

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In Silico Exploration of Hsp90 as a Therapeutic Target in Skin Cancer: Computational Perspectives

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