![](images/logo.png?v=2)
International Journal For Multidisciplinary Research
E-ISSN: 2582-2160
•
Impact Factor: 9.24
A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal
Home
Research Paper
Submit Research Paper
Publication Guidelines
Publication Charges
Upload Documents
Track Status / Pay Fees / Download Publication Certi.
Editors & Reviewers
View All
Join as a Reviewer
Reviewer Referral Program
Get Membership Certificate
Current Issue
Publication Archive
Conference
Publishing Conf. with IJFMR
Upcoming Conference(s) ↓
WSMCDD-2025
Conferences Published ↓
RBS:RH-COVID-19 (2023)
ICMRS'23
PIPRDA-2023
Contact Us
Plagiarism is checked by the leading plagiarism checker
Call for Paper
Volume 6 Issue 4
July-August 2024
Indexing Partners
![Academia.edu Academia](images/index-partners/academia.png)
![Advanced Sciences Index Advanced Sciences Index](images/index-partners/advanced-sciences.png)
![Bielefeld Academic Search Engine Bielefeld Academic Search Engine](images/index-partners/bielefeld.gif)
![CiteSeer CiteSeer](images/index-partners/cite-seer.png)
![DRJI DRJI](images/index-partners/drji.png)
![Google Scholar Google Scholar](images/index-partners/google-scholar.png)
![Independent Search Engine & Directory Network (isedn.org) Independent Search Engine & Directory Network](images/index-partners/isedn.jpg)
![ISI (International Scientific Indexing) ISI (International Scientific Indexing)](images/index-partners/isi.png)
![Issuu Issuu](images/index-partners/issuu.png)
![Mendeley Research Networks Mendeley Research Networks](images/index-partners/mendeley.png)
![RefSeek RefSeek](images/index-partners/ref-seek.png)
![ResearcherId - Thomson Reuters ResearcherId - Thomson Reuters](images/index-partners/researcher-id.png)
![ResearchGate ResearchGate](images/index-partners/research-gate.png)
![Scirus Scirus](images/index-partners/scirus.png)
![Scribd Scribd](images/index-partners/scribd.gif)
![Semantic Scholar Semantic Scholar](images/index-partners/semantic-scholar.png)
![UTeM - Universiti Teknikal Malaysia Melaka UTeM - Universiti Teknikal Malaysia Melaka](images/index-partners/utem.png)
![Wiki for Call for Papers Wiki for Call for Papers](images/index-partners/wiki-cfp.png)
![WorldCat WorldCat](images/index-partners/world-cat.png)
Development and Validation of Stability Indicating by UV Spectrophotometric Method for Determination of Ketoconazole in Both Bulk and Marketed Dosage Formulation
Author(s) | Megha V. Hange, Owais Tamboli, Mahaveer Tathed, Tamanna Shah, P.N.Sable, Rajnandini Yewale |
---|---|
Country | India |
Abstract | In this study, a simple, rapid, accurate, precise and sensitive UV-visible spectrophotometric method has been developed and validated for the determination of ketoconazole in Pharmaceutical Tablet Formulation A UV spectroscopic method which is simple, accurate and rapid is developed for the determination of ketoconazole in pharmaceutical formulations as active substance in tablets, shampoos and cream. The absorption maxima of ketoconazole solutions in methanol are recorded at 208 nm. The linearity for ketoconazole in methanol with correlation coefficient values higher than 0.999 is found in the range of 0.005–0.025 mg/ml at 208 nm, R2 = 0.9996 and 0.05–0.25 mg/ml at 296 nm, R2 = 0.9996. The limit of detection (LOD) and the limit of quantification (LOQ) accounts to 0.000597 mg/ml and 0.00181 mg/ml at 208 nm and 0.00647 mg/ml and 0.01963 mg/ml at 210 nm, respectively. The intra and interday assay is within 2% relative standard deviation. The obtained results for tablets, cream and shampoos are in good agreement with their respective product, label claims. The developed method can be successfully applied for the purpose routine analysis of ketoconazole in pharmaceutical formulations. |
Keywords | Antifungal drug, Formulations, Ketoconazole, UV spectroscopy |
Field | Medical / Pharmacy |
Published In | Volume 6, Issue 3, May-June 2024 |
Published On | 2024-06-13 |
Cite This | Development and Validation of Stability Indicating by UV Spectrophotometric Method for Determination of Ketoconazole in Both Bulk and Marketed Dosage Formulation - Megha V. Hange, Owais Tamboli, Mahaveer Tathed, Tamanna Shah, P.N.Sable, Rajnandini Yewale - IJFMR Volume 6, Issue 3, May-June 2024. DOI 10.36948/ijfmr.2024.v06i03.22536 |
DOI | https://doi.org/10.36948/ijfmr.2024.v06i03.22536 |
Short DOI | https://doi.org/gtzjhh |
Share this
E-ISSN 2582-2160
![](images/ean-13-barcode.gif)
CrossRef DOI is assigned to each research paper published in our journal.
IJFMR DOI prefix is
10.36948/ijfmr
Downloads
All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.
![](images/loading.gif)