Laboratory confirmed Puerperal Sepsis and Associated Factors Among Post Delivery Women Admitted at Bugando Medical Centre,Sekou Toure and Sengerema Hospitals in Mwanza ,Tanzania.

George R. Alcard; Edgar Ndaboine; Jeremiah Seni; Martha F.Mushi; Seth Rwekaza

doi:10.36948/ijfmr.2024.v06i04.24725

Laboratory confirmed Puerperal Sepsis and Associated Factors Among Post Delivery Women Admitted at Bugando Medical Centre,Sekou Toure and Sengerema Hospitals in Mwanza ,Tanzania.

Author(s)	George R. Alcard, Edgar Ndaboine, Jeremiah Seni, Martha F.Mushi, Seth Rwekaza
Country	Tanzania
Abstract	ABSTRACT Background: Puerperal sepsis is one of the leading causes of preventable maternal morbidity and mortality. It accounts for about 11 % of maternal death worldwide, with highest prevalence being reported from low-income countries. However, in Mwanza data on the proportion of post-delivery women with laboratory confirmed puerperal sepsis, bacterial patterns and associated factors were still limited. This is turn limits institution of specific antimicrobial therapies for this population. Objective: To determine the proportion of laboratory confirmed puerperal sepsis, associated factors and bacterial patterns among post-delivery women with clinical features of puerperal sepsis admitted at BMC, SRRH and SDDH in Mwanza, Tanzania. Methodology: A cross-sectional analytical hospital based study involving 340 post-delivery women admitted at BMC (152), SRRH(108) and SDDH (80) was conducted between October 2017 to April 2018.A structured pre-tested questionnaire was used to obtain socio- demographic, clinical and obstetric information from the participants. The endocervical swab and venous blood were aseptically taken for culture and antimicrobial susceptibility testing as per standard operating procedures. Data were analysed using STATA version 13 according to objectives of the study. RESULTS; The mean age of the study participant was 26.2 ± 6.5 years. The proportion of laboratory confirmed puerperal sepsis was 58.8% (200/340). Of these, 164 (82%) had positive culture for endocervical swabs, 17 (8.5%) were blood culture positive and 19 (9.5%) had positive culture results from both blood and endocervical swabs. Staphylococcus aureus were the most predominant bacteria isolate from blood culture 13 (36.1%), while the Escherichia coli 52 (26.0%) were the most predominant bacteria isolated from the endocervical swabs. All Staphylococcus aureus (except one strain) were sensitive to gentamicin and vancomycin. Over three quarter of E.coli was resistance to ampicilin, trimethoprim-sulfamethoxazole, amoxicillin-clavulanate and ceftriaxone; and none of these were resistant to meropenem. Acinetobacter spp. were mostly multidrug resistance, with variable resistance to meropenem (0% to 20%). On multivariable logistic regression analysis, primipara (OR: 10.14, 95%CI: 4.20-24.46, P<0.001), grand multipara OR: 3.85, 95%CI: 1.52-9.74, P=0.004, premature rupture of membrane with OR: 4.31, 95%CI: 1.61-11.47, P=0.003 , pre/eclampsia OR: 3.66, 95%CI: 1.7-11.40, P=0.025, anemia OR: 2.56, 95%CI: 1.20-5.79, P=0.018 and prolonged labor duration OR: 12.69, 95%CI: 5.7-28.0, P=<0.001 were found to be independent predictors of laboratory confirmed puerperal sepsis CONCLUSION: Approximately 60% of women with clinical features of puerperal sepsis had laboratory confirmed puerperal sepsis, with Staphylcococcus aureus and E. coli being predominant bacteria species. High resistance to various agents among bacteria recovered calls for laboratory guided specific antimicrobial therapies to ensure favourable patients outcomes. Patients with premature rupture of membranes, prolonged duration of labours and co-morbid conditions such as anaemia and pre/eclamsia should be targets for preventive measures against puerperal sepsis.
Keywords	Puerperal Sepsis, Associated factors, bacterial pattern
Field	Medical / Pharmacy
Published In	Volume 6, Issue 4, July-August 2024
Published On	2024-07-20
Cite This	Laboratory confirmed Puerperal Sepsis and Associated Factors Among Post Delivery Women Admitted at Bugando Medical Centre,Sekou Toure and Sengerema Hospitals in Mwanza ,Tanzania. - George R. Alcard, Edgar Ndaboine, Jeremiah Seni, Martha F.Mushi, Seth Rwekaza - IJFMR Volume 6, Issue 4, July-August 2024. DOI 10.36948/ijfmr.2024.v06i04.24725
DOI	https://doi.org/10.36948/ijfmr.2024.v06i04.24725
Short DOI	https://doi.org/gt43v5

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Laboratory confirmed Puerperal Sepsis and Associated Factors Among Post Delivery Women Admitted at Bugando Medical Centre,Sekou Toure and Sengerema Hospitals in Mwanza ,Tanzania.

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