International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Formulation and Evaluation of Extended Release Matrix Tablets of Lamotrigine

Author(s) Vimalraj M, Sakthivel D, Rameena P, Kumarasamy Raja D
Country India
Abstract For extended release drug delivery systems, the oral route of drug administration has, by far received more attention as it is natural uncomplicated, convenient and safer route. Matrix tablets composed of drug and release retarding material (e.g. polymer) offer the simplest approach in designing the extended release system. Long-term adherence to anti-epilepsy drug (AED) regimens is frequently suboptimal. Poor adherence to therapy is associated with a number of negative consequences, including an increase in patient seizures and mortality. The present study was aimed to study the effect of Chitosan and Sodium Alginate on the release rate Lamotrigine for the preparation of extended release formulations. Matrix Tablets were prepared by wet granulation method and subjected for Physiochemical and in-vitro evaluation tests. The results were shown that the prepared were found to be within the pharmacopeial limit and with good release characteristics.
Keywords Lamotrigine, Chitosan, Sodium Alginate, Extended release, Matrix Tablets
Field Medical / Pharmacy
Published In Volume 6, Issue 4, July-August 2024
Published On 2024-07-20
Cite This Formulation and Evaluation of Extended Release Matrix Tablets of Lamotrigine - Vimalraj M, Sakthivel D, Rameena P, Kumarasamy Raja D - IJFMR Volume 6, Issue 4, July-August 2024. DOI 10.36948/ijfmr.2024.v06i04.24909
DOI https://doi.org/10.36948/ijfmr.2024.v06i04.24909
Short DOI https://doi.org/gt43s3
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