International Journal For Multidisciplinary Research
E-ISSN: 2582-2160
•
Impact Factor: 9.24
A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal
Home
Research Paper
Submit Research Paper
Publication Guidelines
Publication Charges
Upload Documents
Track Status / Pay Fees / Download Publication Certi.
Editors & Reviewers
View All
Join as a Reviewer
Reviewer Referral Program
Get Membership Certificate
Current Issue
Publication Archive
Conference
Publishing Conf. with IJFMR
Upcoming Conference(s) ↓
WSMCDD-2025
GSMCDD-2025
Conferences Published ↓
RBS:RH-COVID-19 (2023)
ICMRS'23
PIPRDA-2023
Contact Us
Plagiarism is checked by the leading plagiarism checker
Call for Paper
Volume 6 Issue 6
November-December 2024
Indexing Partners
Gastro Retentive Drug Delivery System: A Review
Author(s) | Gautami Durgam, Supriya Gadave |
---|---|
Country | India |
Abstract | The aim of a gastro-retentive drug delivery system (GRDDS) is to target site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects by maintaining the dose form in the stomach for a prolonged amount of time. The goal of this strategy is to extend the gastric residency period, which is crucial for medications that need to be released specifically in the upper intestine or stomach to improve absorption. GRDDS are especially helpful for medications with shorter half-lives, unstable or poorly soluble at alkaline pH, or poor absorption in the lower gastrointestinal tract. To accomplish the necessary retention time and release pattern, the system can be constructed employing a variety of cutting-edge techniques, such as floating, bioadhesive, expandable, or magnetic systems. Recent years have seen a huge increase in the use gastro-retentive drug delivery system (GRDDS) for oral medication delivery. Effective GRDDS have been designed using variety of creative techniques such as widely adopted floating drug delivery system (FDDS). GRDDS offers several benefits such as delivering medications with limited absorption window, enhancing pharmacological effects, reducing dosage frequency, improving bioavailability and having longer residence time in the stomach for local action like treating peptic ulcer disease. This paper aims to provide a quick overview of gastro retentive drug delivery (GRDD), including its need, advantages, disadvantages, factors affecting, approach and also its applications. |
Keywords | Gastroretentive, GRDDS, bioadhesive, bioavailability, gastrointestinal tract, floating drug delivery system. |
Field | Medical / Pharmacy |
Published In | Volume 6, Issue 4, July-August 2024 |
Published On | 2024-08-06 |
Cite This | Gastro Retentive Drug Delivery System: A Review - Gautami Durgam, Supriya Gadave - IJFMR Volume 6, Issue 4, July-August 2024. DOI 10.36948/ijfmr.2024.v06i04.25651 |
DOI | https://doi.org/10.36948/ijfmr.2024.v06i04.25651 |
Short DOI | https://doi.org/gt65jb |
Share this
E-ISSN 2582-2160
doi
CrossRef DOI is assigned to each research paper published in our journal.
IJFMR DOI prefix is
10.36948/ijfmr
Downloads
All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.