International Journal For Multidisciplinary Research

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A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 6 Issue 6 November-December 2024 Submit your research before last 3 days of December to publish your research paper in the issue of November-December.

Gastro Retentive Drug Delivery System: A Review

Author(s) Gautami Durgam, Supriya Gadave
Country India
Abstract The aim of a gastro-retentive drug delivery system (GRDDS) is to target site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects by maintaining the dose form in the stomach for a prolonged amount of time. The goal of this strategy is to extend the gastric residency period, which is crucial for medications that need to be released specifically in the upper intestine or stomach to improve absorption. GRDDS are especially helpful for medications with shorter half-lives, unstable or poorly soluble at alkaline pH, or poor absorption in the lower gastrointestinal tract. To accomplish the necessary retention time and release pattern, the system can be constructed employing a variety of cutting-edge techniques, such as floating, bioadhesive, expandable, or magnetic systems. Recent years have seen a huge increase in the use gastro-retentive drug delivery system (GRDDS) for oral medication delivery. Effective GRDDS have been designed using variety of creative techniques such as widely adopted floating drug delivery system (FDDS). GRDDS offers several benefits such as delivering medications with limited absorption window, enhancing pharmacological effects, reducing dosage frequency, improving bioavailability and having longer residence time in the stomach for local action like treating peptic ulcer disease. This paper aims to provide a quick overview of gastro retentive drug delivery (GRDD), including its need, advantages, disadvantages, factors affecting, approach and also its applications.
Keywords Gastroretentive, GRDDS, bioadhesive, bioavailability, gastrointestinal tract, floating drug delivery system.
Field Medical / Pharmacy
Published In Volume 6, Issue 4, July-August 2024
Published On 2024-08-06
Cite This Gastro Retentive Drug Delivery System: A Review - Gautami Durgam, Supriya Gadave - IJFMR Volume 6, Issue 4, July-August 2024. DOI 10.36948/ijfmr.2024.v06i04.25651
DOI https://doi.org/10.36948/ijfmr.2024.v06i04.25651
Short DOI https://doi.org/gt65jb

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