International Journal For Multidisciplinary Research

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Development of Analytical Technique for Dichlofenac Sodium and Ibuprofen Utilizing UV Visible Spectroscopy and AUC Method

Author(s) Ankit C. Rathod, Ankush R. Dudhe, Krushna H. Gajare
Country India
Abstract The purpose of this work was to create an analytical method combining UV visible spectroscopy and the AUC method for the simultaneous determination of diclofenac sodium and ibuprofen in their combination dosage form. The medications’ UV spectra were captured between 200 and 400 nm, and the calibration curves were built using AUC values for diclofenac sodium and ibuprofen at 274 nm and 222 nm, respectively. The developed method’s linearity, precision, accuracy, limit of detection, and limit of quantification were all validated in accordance with ICH recommendations. The findings demonstrated that the approach was linear, exact, accurate, and sensitive for the measurement of ibuprofen and diclofenac sodium. Without any excipient interference, the suggested approach was effectively used to determine the two medicines in their combination dose form. The created approach is straightforward, accurate, and cost-effective, and it may be utilised for regular analysis of ibuprofen and diclofenac sodium in their combination dose form.
Keywords Dichlofinac sodium, ibuprofen, AUC, UV Spectroscopy, method Development
Field Medical / Pharmacy
Published In Volume 5, Issue 2, March-April 2023
Published On 2023-04-24
Cite This Development of Analytical Technique for Dichlofenac Sodium and Ibuprofen Utilizing UV Visible Spectroscopy and AUC Method - Ankit C. Rathod, Ankush R. Dudhe, Krushna H. Gajare - IJFMR Volume 5, Issue 2, March-April 2023. DOI 10.36948/ijfmr.2023.v05i02.2570
DOI https://doi.org/10.36948/ijfmr.2023.v05i02.2570
Short DOI https://doi.org/gr6h8b
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