Methods to Enhance Mechanical Strength of 3D Printed Chitosan Scaffolds for Jawbone Regeneration

Zaara

doi:10.36948/ijfmr.2024.v06i05.25907

Methods to Enhance Mechanical Strength of 3D Printed Chitosan Scaffolds for Jawbone Regeneration

Author(s)	Zaara
Country	Indonesia
Abstract	Current jaw reconstruction methods using autografts and allografts have limitations such as donor site morbidity, limited bone volume, and immunological rejection. As opposed to surgical methods synthetic biomaterials are used however they often fall short in providing the optimal combination of biocompatibility, mechanical strength, and customizable design required for effective jawbone reconstruction. 3D-printed chitosan scaffolds offer a promising alternative due to their biocompatibility, ease of customization, and potential for improved mechanical strength. This review explores strategies to optimize 3D-printed chitosan scaffolds for jaw reconstruction. We examine ways to increase their mechanical strength without compromising biocompatibility, with a particular emphasis on chemical modifications such as hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) cross-linking and chitosan polyelectrolyte complex formation. We also discuss the critical roles that 3D printing processes (FDM and SLA) and intrinsic chitosan qualities (degree of deacetylation) play in making an ink printable. Optimizing 3D printing methods for chitosan-ceramic composites and exploring biocompatible additives to enhance printability are identified as key areas for further research. By addressing these challenges, 3D-printed chitosan scaffolds have the potential to become next-generation biomaterials for jaw reconstruction, revolutionizing the field through precise anatomical adaptation, enhanced osteoconductivity, controlled biodegradation, and the capacity for incorporating bioactive molecules, ultimately leading to accelerated bone regeneration and improved functional and aesthetic outcomes.
Keywords	Biomedical engineering, Cell and tissue engineering, 3D printing, jawbone regeneration, chitosan
Field	Medical / Pharmacy
Published In	Volume 6, Issue 5, September-October 2024
Published On	2024-10-06
Cite This	Methods to Enhance Mechanical Strength of 3D Printed Chitosan Scaffolds for Jawbone Regeneration - Zaara - IJFMR Volume 6, Issue 5, September-October 2024. DOI 10.36948/ijfmr.2024.v06i05.25907
DOI	https://doi.org/10.36948/ijfmr.2024.v06i05.25907
Short DOI	https://doi.org/g795hm

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Methods to Enhance Mechanical Strength of 3D Printed Chitosan Scaffolds for Jawbone Regeneration

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