International Journal For Multidisciplinary Research

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Unraveling the Anti-epileptic Potential of Pavonia Procumbens: Phytochemical Insights and Neuroprotective Potential

Author(s) L. Parameshwari, N.Senthil kumar, E.Thilagam
Country India
Abstract Abstract
There remains a significant challenge when it comes to managing epilepsy despite the advancement of diagnostic techniques, so alternatives like traditional medicine are being explored. It is the purpose of this study to investigate the mechanisms underlying Pavonia's antiepileptic effect. Flavonoid was identified as a major component of Pavonia extracts by phytochemical analysis. A significant scavenging effect of EEPP was observed at 88.03 % and 88.26 % against superoxide and hydroxyl radicals, similar to standard drug rutin. This study found that EEPP inhibited 95.69% of the lipid peroxidation induced by Fe2+/ascorbate, which was comparable to the activity of rutin (87.77%). EEPP inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in a concentration-dependent manner. As a result of increasing concentrations (10-500 g/ml), the inhibitory ability of the drug increased from 13.36% to 88.53%, paralleling standard drug efficacy (33.44%-94.56%). Additionally, BuChE inhibition was also up from 7.05% to 79.36%, reflecting standard efficacy (22.36%-83.35%). There is no doubt that EEPP inhibits both enzymes more effectively than the standard, although it requires higher concentrations to be equally effective. Based on these findings, Pavonia may be effective at treating anxiety related to epilepsy. It has been suggested that cholinergic modulation may be involved in Pavonia's efficacy. It will be important to elucidate the neurobiological mechanisms behind EEPP, validate findings in animal models, identify bioactive compounds, as well as investigate broader neuroprotective effects in future research. In the context of neurological diseases, EEPP offers promise as an adjunctive therapy.
Keywords Keywords: Epilepsy, Pavonia procumbens, neuroprotective, traditional medicine, cholinesterase inhibition
Field Medical / Pharmacy
Published In Volume 6, Issue 4, July-August 2024
Published On 2024-08-13
Cite This Unraveling the Anti-epileptic Potential of Pavonia Procumbens: Phytochemical Insights and Neuroprotective Potential - L. Parameshwari, N.Senthil kumar, E.Thilagam - IJFMR Volume 6, Issue 4, July-August 2024. DOI 10.36948/ijfmr.2024.v06i04.25988
DOI https://doi.org/10.36948/ijfmr.2024.v06i04.25988
Short DOI https://doi.org/gt65c7
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