International Journal For Multidisciplinary Research

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A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 6 Issue 6 November-December 2024 Submit your research before last 3 days of December to publish your research paper in the issue of November-December.

A Case Report on Bupropion Induced Febrile Delirium & Reversible Liver Injury

Author(s) Jomol Mathew, Jeeva Elizabeth Thomas, S.K Mathew
Country India
Abstract Bupropion, an atypical antidepressant and smoking cessation aid, is generally well-tolerated but has been linked to rare instances of hepatotoxicity. We report a case of a 81-year-old non alcoholic male who developed jaundice, fatigue, and right upper quadrant discomfort three months after starting bupropion. Laboratory tests showed elevated liver enzymes and hyperbilirubinemia, while extensive workup excluded other causes of liver dysfunction. The temporal association with bupropion and exclusion of other etiologies led to a diagnosis of bupropion-induced liver injury. Discontinuation of bupropion and supportive care resulted in gradual improvement and normalization of liver enzymes and resolution of fever and delirium state within three months. This case underscores the importance of considering bupropion-induced febrile delirium and reversible liver injury in patients with unexplained liver dysfunction and highlights the necessity for early recognition and drug cessation for recovery. Bupropion is also known to cause unexplained delirium. Conditions which can result in such a state can range from very diverse perspectives, such as infectious conditions like pneumonia or urinary tract infections, metabolic disorders like electrolyte imbalance, and disorders of the central nervous system like encephalitis. Keen medical evaluation is very essential for determining the root cause, as treatment mostly depends on prompt action for causative diseases to avoid further complications.
Field Medical / Pharmacy
Published In Volume 6, Issue 4, July-August 2024
Published On 2024-08-13
Cite This A Case Report on Bupropion Induced Febrile Delirium & Reversible Liver Injury - Jomol Mathew, Jeeva Elizabeth Thomas, S.K Mathew - IJFMR Volume 6, Issue 4, July-August 2024. DOI 10.36948/ijfmr.2024.v06i04.26050
DOI https://doi.org/10.36948/ijfmr.2024.v06i04.26050
Short DOI https://doi.org/gt65cd

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