International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 6 Issue 6 November-December 2024 Submit your research before last 3 days of December to publish your research paper in the issue of November-December.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 6 Issue 6
November-December 2024

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Development and Validation of UV-Vis Spectroscopic Method for the Determination of Anticancer Drug Crizotinib

Author(s) Mossammat Rima Akter, Md. Saddam Hossain, Md. Tanvir Hossain Amir, Abubakar Sarker, Shomrat Saikh, Tanvin Sultana
Country Bangladesh
Abstract Cancer is one of the most leading causes of death in the recent era. A number of cancers based on the affected organ namely stomach cancer, lung cancer, breast cancer, colon cancer etc. Various anticancer drugs are available worldwide where the topnotch one is tyrosine kinase inhibitor. Crizotinib is the recent INN drug which is a tyrosine kinase inhibitor and indicated for non-small cell lung cancer. It is revealed from literature review, there are no developed methods available for determination of crizotinib except HPLC and UPLC methods. In the present study, authors aimed to develop and validate the method based on UV-vis spectroscopy for determination of crizotinib. Crizotinib showed wavelength max (λmax) at 220 nm and 275 nm with a regression equation of y = 0.075x + 0.001, the correlation of Determination (R²) was 0.999, and the correlation coefficient (r) was 0.9995 which indicate the outstanding correlation between concentrations and absorbances along with linearity of the method. The dynamic range was found 1.25 μg/mL to 20 μg/mL for the method. The % RSD of robustness, precision, ruggedness was below 2. Limit of detection and limit of quantification were detected 0.264 μg/mL and 0.8 μg/mL respectively. This paper introduces a new accurate, precise, and simple method for the analysis of crizotinib. The newly developed method can be used for routine quality control of crizotinib.
Keywords Method, Validation, Crizotinib, Anticancer drug, Accuracy, Linearity
Field Chemistry > Pharmacy
Published In Volume 6, Issue 4, July-August 2024
Published On 2024-08-30
Cite This Development and Validation of UV-Vis Spectroscopic Method for the Determination of Anticancer Drug Crizotinib - Mossammat Rima Akter, Md. Saddam Hossain, Md. Tanvir Hossain Amir, Abubakar Sarker, Shomrat Saikh, Tanvin Sultana - IJFMR Volume 6, Issue 4, July-August 2024. DOI 10.36948/ijfmr.2024.v06i04.26567
DOI https://doi.org/10.36948/ijfmr.2024.v06i04.26567
Short DOI https://doi.org/gt8gxw
View / Download PDF File

Share this



E-ISSN 2582-2160
CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJFMR DOI prefix is
10.36948/ijfmr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 6 Isu 6Cover Page Vol 6 Isu 5Cover Page Vol 6 Isu 4

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJFMR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9898-5948-55 editor@ijfmr.com