Development and Application of HPLC and UFLC Methods for the Analysis of Anti Histaminic Drugs

Rajpurohit Bhavesh; Kiran Joshi; Priyadarshini Ravindra Kamble

doi:10.36948/ijfmr.2024.v06i04.26614

Development and Application of HPLC and UFLC Methods for the Analysis of Anti Histaminic Drugs

Author(s)	Rajpurohit Bhavesh, Kiran Joshi, Priyadarshini Ravindra Kamble
Country	India
Abstract	Research focused on medications used to treat allergic reactions. The results of this inquiry were contrasted with those that had already been released. In comparison to other works in the literature, it was determined that the current study had the best complete baseline separation and lowest detection limit. The retention, separation, and resolution factors were discovered to have ranges of 0.07-9.14, 1.44-4.21, and 2.15-18.66, respectively. The SPE and UFLC techniques created and verified for this purpose were used to examine human plasma samples for the presence of antihistaminic drugs. Peak retention, separation, resolution, and symmetry all matched the reference samples' values. The results for symmetry, separation, and resolution were all in agreement with the reference samples. The methods used to separate and identify Phenylephrine, cetirizine, loratadine, montelukast, and Ebastine in human plasma were found to be selective, effective, hardy, affordable, environmentally friendly, and reproducible, according to the authors. The selectivity of the SPE technique was validated by the absence of any secondary signal in the plasma samples. Additionally, there was no evidence of these drugs degrading in the plasma sample. This is the initial report on the simultaneous isolation and identification of these eight medications. The well-known SPE and UFLC techniques were successfully used to monitor these drugs in human plasma. Therefore, these drugs can be detected in any plasma sample using SPE or UFLC methods.
Keywords	Solid Phase extraction, Ultra fast liquid chromatography, Anti histaminic drugs
Field	Medical / Pharmacy
Published In	Volume 6, Issue 4, July-August 2024
Published On	2024-08-26
Cite This	Development and Application of HPLC and UFLC Methods for the Analysis of Anti Histaminic Drugs - Rajpurohit Bhavesh, Kiran Joshi, Priyadarshini Ravindra Kamble - IJFMR Volume 6, Issue 4, July-August 2024. DOI 10.36948/ijfmr.2024.v06i04.26614
DOI	https://doi.org/10.36948/ijfmr.2024.v06i04.26614
Short DOI	https://doi.org/gt8gxc

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Development and Application of HPLC and UFLC Methods for the Analysis of Anti Histaminic Drugs

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