International Journal For Multidisciplinary Research

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Serological Evaluation of the Anti-coagulant Activity of the Classical Siddha Medicine -‘Veera Mezhugu’ in Wistar Albino Rats

Author(s) Agasthian A, G.Esakki pandiyan
Country India
Abstract In setting the basis for the management of arterial thrombosis, cardiac ischemic changes followed by any severe coronary atherosclerotic changes or any venous thrombosis, there is a conventional use of Acute thrombolytic agents, Anticoagulants with antiplatelet medications in general.
These symptoms complex are mentioned as Thamaraga vaayu or Ruththira vaayu or Maaradaippu(Acute coronary syndrome) and Uthirakattu(thromboembolism) in siddha literatures.
Veera mezhugu is one of the Siddha formulations chosen from Anuboga vaithiya navaneetham part-4, which is indicated for Uthirakattu and Thamaragavaayu. The drug prepared as per the Siddha literature. The drug has undergone safety studies and the efficacy studies in Wistar albino rats where the serum of the different groups with different doses are compared with the placebo control to evaluate the anti-coagulant potential.
Coagulation profile of the three parameters of Activated partial thromboplastin time(APTT), Prothrombin time(PT) and International normalized ratio(INR) are taken for evaluation and had significant difference between the groups[p<0.05].Serological analysis of the Wistar rats shows significant anticoagulant activity in a dose dependent manner.
Keywords Anti-coagulant, Complementary & Alternative medicine, Veera Mezhugu, Siddha Medicine, Drug development, Ethnopharmacology
Field Medical / Pharmacy
Published In Volume 6, Issue 4, July-August 2024
Published On 2024-08-30
Cite This Serological Evaluation of the Anti-coagulant Activity of the Classical Siddha Medicine -‘Veera Mezhugu’ in Wistar Albino Rats - Agasthian A, G.Esakki pandiyan - IJFMR Volume 6, Issue 4, July-August 2024. DOI 10.36948/ijfmr.2024.v06i04.26620
DOI https://doi.org/10.36948/ijfmr.2024.v06i04.26620
Short DOI https://doi.org/gt8gw7
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