International Journal For Multidisciplinary Research

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Acute Oral Toxicity Study of Abhraka Navaneedha Chenduram - A Classical Siddha Drug

Author(s) A.Santhosh Sivan, R.Anthony duraichi, G.Esakki Pandian
Country India
Abstract Biotite mica , known as Krishna abhrakam a rock forming mineral has been processed and used as medicine in siddha system of medicine. Numerous preparations containing abhrakam were found in siddha literature. Abhraka navaneedha chenduram is one such preparation found in Agasthiar chenduram 300 a classical siddha literature mentioned for treating mega neer ( Diseases having polyurea as predominant symptom) .In this study acute oral toxicity of abhraka navaneedha chenduram in wistar albino rats as per OECD 423 guidelines was performed. Abhraka navaneedha chenduram(ABNC) was administered at 2000mg/kg P.O in female wistar rats and animals were observed for toxic signs for first 30 minutes , 1st , 2nd, 4th and 6th hours on the day of dosing and next 14 days. Gross pathology was performed at the end of the study. No treatment related deaths , toxic signs and gross pathological changes were observed with abhraka navaneedha chenduram administration. Acute oral toxicity study reveals that LD50 of abhraka navaneedha chenduram is greater than 2000mg\kg body weight in fasted female wistar rats and can be classified as Globally Harmonized system of classification and labelling of chemicals (GHS) category 5.
Keywords Abhraka navaneedha chenduram , Acute oral toxicity , siddha drug
Field Medical / Pharmacy
Published In Volume 6, Issue 5, September-October 2024
Published On 2024-09-04
Cite This Acute Oral Toxicity Study of Abhraka Navaneedha Chenduram - A Classical Siddha Drug - A.Santhosh Sivan, R.Anthony duraichi, G.Esakki Pandian - IJFMR Volume 6, Issue 5, September-October 2024. DOI 10.36948/ijfmr.2024.v06i05.26833
DOI https://doi.org/10.36948/ijfmr.2024.v06i05.26833
Short DOI https://doi.org/gt9kt4
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