International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

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Pathophysiology of Stroke: A Molecular Mechanism Perspective

Author(s) Avani Joshi, Kausar Sanghani, Mihir Bhatt, Akshita Maradiya, Sachin Bhatt
Country India
Abstract Stroke is a major cause of death and disability worldwide. The Resulting burden on the society continues to grow, with increase in the incidence of Stroke. Brain attack is a term introduced to describe the acute presentation of stroke, which emphasizes the need for urgent action to remedy the situation. While these observations underpinned key trials of thrombolysis, they also indicate that only patients who are likely to benefit should be exposed to its risks. This review explores the etiology and pathogenesis of ischemic stroke, and provides general information of model. This literature review examines the risk factors associated with ischemic stroke, changes in cell morphology and signaling in the brain after stroke. The Pathophysiology of cerebral ischemic injury is explained, and experimental animal models of global and focal ischemic stroke, and in vitro cellular stroke models, are described in details along with mechanism. This article is dedicated to acute ischemic strokes and its molecular mechanism. Classification systems for stroke a etiology are also discussed briefly, as well as current ischemic stroke therapies and new therapeutic strategies and clinical studies that focus on the potential of stroke recovery.
Keywords Ischemic Stroke, Hypertension, Microglia Cells, Neutrophils, Thrombosis, Embolism
Field Medical / Pharmacy
Published In Volume 5, Issue 2, March-April 2023
Published On 2023-04-28
DOI https://doi.org/10.36948/ijfmr.2023.v05i02.2693
Short DOI https://doi.org/gr7hh7
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E-ISSN 2582-2160
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