Challenges in Managing Insulinomas and Hyperparathyroidism in MEN1:  A Clinical Case Study

HAYAT AYNAOU; HOUDA SALHI

doi:10.36948/ijfmr.2024.v06i05.28136

Challenges in Managing Insulinomas and Hyperparathyroidism in MEN1: A Clinical Case Study

Author(s)	HAYAT AYNAOU, HOUDA SALHI
Country	Maroc
Abstract	Pancreatic insulinoma is an uncommon neuroendocrine tumor with an incidence of approximately 1 per million people annually. While the majority of insulinomas are sporadic, a minority are associated with Multiple Endocrine Neoplasia type 1 (MEN1), a rare genetic disorder transmitted in an autosomal dominant pattern. MEN1 is characterized by the presence of hyperplastic or adenomatous parathyroid glands, pancreatic islet cell tumors, and pituitary tumors. The disorder can also involve lesions in the duodenum, adrenal glands, thymus, and bronchi. We report a case of MEN1 presenting with multiple insulinomas in a 37-year-old male, who exhibited symptoms of intermittent hypoglycemia over a decade. Diagnostic workup included biochemical assays , and imaging studies that revealed elevated insulin and C-peptide levels and hypervascular pancreatic lesions, , and pathological findings consistent with MEN1. Surgical intervention involved the enucleation of insulinomas and distal pancreatectomy, followed by removal of parathyroid adenomas. The postoperative evolution was marked by the resolution of hypoglycemic episodes and the persistence of primary hyperparathyroidism. This case underscores the complexity of diagnosing and managing insulinomas within the context of MEN1. It highlights the importance of a multidisciplinary approach to treatment and the need for ongoing surveillance to address both endocrine manifestations and psychological impacts. The findings advocate for comprehensive management strategies and support systems to improve patient outcomes and quality of life.
Keywords	Hypoglycemia, Pancreatic Insulinoma, Multiple Endocrine Neoplasia Type 1 (MEN1), Primary Hyperparathyroidism, Genetic Disorders
Field	Médical / Pharmacie
Published In	Volume 6, Issue 5, September-October 2024
Published On	2024-10-08
Cite This	Challenges in Managing Insulinomas and Hyperparathyroidism in MEN1: A Clinical Case Study - HAYAT AYNAOU, HOUDA SALHI - IJFMR Volume 6, Issue 5, September-October 2024. DOI 10.36948/ijfmr.2024.v06i05.28136
DOI	https://doi.org/10.36948/ijfmr.2024.v06i05.28136
Short DOI	https://doi.org/g795gk

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Challenges in Managing Insulinomas and Hyperparathyroidism in MEN1: A Clinical Case Study

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