In-silico Evaluation of Moringa Oleifera Phytochemicals as Inhibitors Against Newcastle Disease Virus in Birds

Umar Aliyu Adamu; Ramgopal Dhakar; Pankaj Kumar Teli; Saminu Saminu Muhammad; Ibrahim Abdullahi Gumel

doi:10.36948/ijfmr.2024.v06i05.28385

In-silico Evaluation of Moringa Oleifera Phytochemicals as Inhibitors Against Newcastle Disease Virus in Birds

Author(s)	Umar Aliyu Adamu, Ramgopal Dhakar, Pankaj Kumar Teli, Saminu Saminu Muhammad, Ibrahim Abdullahi Gumel
Country	India
Abstract	Newcastle disease (ND) is a highly contagious viral infection that significantly impacts the global poultry industry, leading to substantial economic losses due to high mortality rates. Despite the availability of vaccines, the persistent threat of ND necessitates the exploration of novel therapeutic strategies. Moringa oleifera, commonly known as the "miracle tree," is renowned for its diverse pharmacological properties, including antiviral, antioxidant, and immunomodulatory effects. This study investigates the potential of Moringa oleifera phytochemicals as inhibitors of the Newcastle disease virus (NDV) through molecular docking analysis. The research focuses on identifying bioactive compounds within Moringa oleifera that exhibit strong binding affinities to the fragment of fusion protein of NDV, a critical component in the virus's ability to infect host cells. By employing in silico methods, the study predicts the efficacy of these compounds in disrupting NDV activity, offering a promising new avenue for ND treatment and prevention. The findings suggest that specific phytochemicals, such as Beta Sitosterol, catechins, and Kaempferol, demonstrate significant binding affinities, (with binding scores of -8.5 kcal/mol, -8.2 kcal/mol and -7.9 kcal/mol respectively), making them potential candidates for further development into antiviral therapies. This approach underscores the potential of Moringa oleifera in enhancing the resilience of the poultry industry against Newcastle disease, thereby contributing to improved food security and economic stability.
Keywords	Newcastle disease, Moringa oleifera, Molecular docking, Fusion protein, Poultry industry,
Field	Biology > Genetics / Molecular
Published In	Volume 6, Issue 5, September-October 2024
Published On	2024-10-06
Cite This	In-silico Evaluation of Moringa Oleifera Phytochemicals as Inhibitors Against Newcastle Disease Virus in Birds - Umar Aliyu Adamu, Ramgopal Dhakar, Pankaj Kumar Teli, Saminu Saminu Muhammad, Ibrahim Abdullahi Gumel - IJFMR Volume 6, Issue 5, September-October 2024. DOI 10.36948/ijfmr.2024.v06i05.28385
DOI	https://doi.org/10.36948/ijfmr.2024.v06i05.28385
Short DOI	https://doi.org/g7945z

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In-silico Evaluation of Moringa Oleifera Phytochemicals as Inhibitors Against Newcastle Disease Virus in Birds

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