Zebrafish: A Versatile Animal Model in Biomedical Research

Vinayaka Madivalar; Mallappa Shalavdi; Shubham Teli; Gouthamachari Shrinivas; Anjana Kulkarni

doi:10.36948/ijfmr.2024.v06i05.28747

Zebrafish: A Versatile Animal Model in Biomedical Research

Author(s)	Vinayaka Madivalar, Mallappa Shalavdi, Shubham Teli, Gouthamachari Shrinivas, Anjana Kulkarni
Country	India
Abstract	Zebrafish (Danio rerio) has emerged as a powerful animal model in biomedical research, offering a unique combination of genetic tractability, rapid development, and conserved gene function with humans. This review highlights the significance of zebrafish in understanding various human diseases, including neurodegenerative disorders, metabolic disorders, cancer, and more. The zebrafish genome, with over 70% similarity to the human genome, allows for the modelling of human diseases with high fidelity. The ease of genetic manipulation, high fecundity, and low maintenance costs make zebrafish an attractive model for large-scale genetic screens and drug discovery. Zebrafish models of neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease, have been developed, providing insights into disease mechanisms and potential therapeutic targets. Similarly, zebrafish models of metabolic disorders, including diabetes, dyslipidaemia, and atherosclerosis, have been established, enabling the study of disease pathogenesis and prevention strategies.The zebrafish has also been used to model various types of cancer, including leukaemia, melanoma, and pancreatic cancer, facilitating the discovery of novel oncogenes and tumor suppressors. The transparent nature of zebrafish embryos and larvae allows for in vivo imaging of cancer cells, enabling the study of cancer cell behavior and response to therapy. Furthermore, zebrafish has been used to investigate brain-to-organ communication, cell transplantation, and cell-cell interactions, providing insights into the complex interactions between different tissues and organs. The development of novel tools, such as CRISPR/Cas9 genome editing and single-cell RNA sequencing, has further expanded the capabilities of zebrafish research.
Keywords	Zebrafish, applications, animal model, biology,
Field	Medical / Pharmacy
Published In	Volume 6, Issue 5, September-October 2024
Published On	2024-10-18
Cite This	Zebrafish: A Versatile Animal Model in Biomedical Research - Vinayaka Madivalar, Mallappa Shalavdi, Shubham Teli, Gouthamachari Shrinivas, Anjana Kulkarni - IJFMR Volume 6, Issue 5, September-October 2024. DOI 10.36948/ijfmr.2024.v06i05.28747
DOI	https://doi.org/10.36948/ijfmr.2024.v06i05.28747
Short DOI	https://doi.org/g8nqbf

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Zebrafish: A Versatile Animal Model in Biomedical Research

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