Formulation and Evaluation of Mucoadhesive Microsphere of Esomeprazole and Domperidone

Author(s)	Vijaya P. Sonwane, Sachin B. Dudhe
Country	India
Abstract	Purpose: To prepare and evaluate mucoadhesive microsphere of esomeprazole and domperidone for the treatment of gastroesophageal reflux disease Methods: The microspherewere prepared by solvent evaporation technique by using sodium carboxy methyl cellulose and sodium alginate as polymer. Esomeprazole and Domperidone was entrapped in the microsphere at various polymer. The microsphere were evaluated for their micromeretic properties and in- vitro release. Results: The microspheres were discrete, spherical and showed good drug entrapment efficiency. Results indicate that the drug was compatible with the polymer used. Amongst all the formulations, F6 showed the most suitable sustain release properties with 97.75 % of drug released at the end of 24 hrs. Conclusion: Microsphere prepared using sodium carboxy methyl cellulose and sodium alginate can be used as a sustained release delivery system for esomeprazole and domperidone.
Keywords	Microsphere, Solvent Evaporation, Esomeprazole, Domperidone, Sustain Release.
Field	Medical / Pharmacy
Published In	Volume 6, Issue 5, September-October 2024
Published On	2024-10-31
DOI	https://doi.org/10.36948/ijfmr.2024.v06i05.29677
Short DOI	https://doi.org/g8p2sq

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