International Journal For Multidisciplinary Research

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Anesthetic Approach in Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Ovarian Teratoma: A Case Report

Author(s) Resiah Loraine Dela Cruz Sanqui, Karl Matthew Co Sy Su
Country Philippines
Abstract Autoimmune encephalitis associated with ovarian teratoma has recently been related to the development of antibodies to specific heteromers of the N-methyl-d-aspartate receptor. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune condition that is brought on by the production of anti-NMDAR antibodies. It frequently presents on young females and manifests in different ways, including psychiatric symptoms, seizures, hypoventilation, and instability of the autonomic nervous system. Patients who have early surgical tumor excision in addition to immunotherapy had better outcomes than the other patients with this condition. Because the NMDAR is one of the main sites of action for frequently used anesthetic drugs, it is crucial to comprehend the pharmacological interaction between the anesthetic agents and the impaired NMDAR in order to build an anesthetic plan. This study describes a young female patient with autoimmune encephalitis who needed to have an ovarian teratoma surgically removed. Surgery was done under general anesthesia and peripheral nerve block (PNB). Sevoflurane and propofol did not appear to alter psychoneuronal function or cause autonomic instability despite their indirect effects on anti-NMDAR. A quadratus lumborum block was performed to reduce the amount of opioids required for anesthesia.
Keywords Keywords: anesthesia, ovarian teratoma, autoimmune encephalitis, anti-NMDA receptor
Field Medical / Pharmacy
Published In Volume 6, Issue 6, November-December 2024
Published On 2024-11-16
Cite This Anesthetic Approach in Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Ovarian Teratoma: A Case Report - Resiah Loraine Dela Cruz Sanqui, Karl Matthew Co Sy Su - IJFMR Volume 6, Issue 6, November-December 2024. DOI 10.36948/ijfmr.2024.v06i06.30618
DOI https://doi.org/10.36948/ijfmr.2024.v06i06.30618
Short DOI https://doi.org/g8rd29
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