International Journal For Multidisciplinary Research

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Current Understanding of the Effects of Sun Exposure on Skin Tanning: Mechanisms, Risks, and Protective Strategies

Author(s) Tilotma Sahu, Dhanisha Sonwanee
Country India
Abstract UV radiation (UV) is designated as a "comprehensive carcinogen" due to its dual nature as a mutagen and a non-specific damaging agent, exhibiting properties of both a tumor initiator and a tumor promoter. UV radiation is the foremost modifiable risk factor for skin cancer and various other environmentally-influenced skin disorders. Nevertheless, UV radiation also plays a beneficial role in human health by facilitating the natural synthesis of vitamin D and endorphins in the skin. Consequently, UV radiation exhibits complex and diverse effects on human health. However, excessive exposure to UV radiation poses significant health risks, including skin atrophy, pigmentary alterations, wrinkling, and malignancy.
Epidemiological and molecular evidence establish a clear link between UV radiation and the three most prevalent types of skin cancer: basal cell carcinoma, squamous cell carcinoma, and malignant melanoma, collectively impacting over a million Americans each year. Furthermore, genetic factors contribute to the susceptibility of UV-mediated skin diseases. Notably, specific variations in the melanocortin 1 receptor (MC1R) gene are associated with skin fairness, UV sensitivity, and heightened cancer risk. In light of these findings, our research aims to develop innovative UV-protective strategies by comprehensively understanding the molecular events that occur following UV exposure, with a specific focus on epidermal melanization and the pivotal role played by the MC1R in maintaining the integrity of the genome.
By leveraging this knowledge, we endeavor to devise pharmaceutical interventions that can effectively mitigate the detrimental effects of UV radiation on the skin, reduce the risk of skin cancer, and enhance skin health. Such advancements will not only contribute to safeguarding individuals from the harmful consequences of excessive UV exposure but also pave the way for novel approaches in the field of dermatology and personalized medicine, tailored to the individual's genetic makeup and specific risk factors.
Keywords UV radiation, dermis, cancer development, genetic mutation, skin pigmentation, malignant tumors, melanin production, MC1R gene.
Field Chemistry > Pharmacy
Published In Volume 5, Issue 3, May-June 2023
Published On 2023-05-19
Cite This Current Understanding of the Effects of Sun Exposure on Skin Tanning: Mechanisms, Risks, and Protective Strategies - Tilotma Sahu, Dhanisha Sonwanee - IJFMR Volume 5, Issue 3, May-June 2023. DOI 10.36948/ijfmr.2023.v05i03.3115
DOI https://doi.org/10.36948/ijfmr.2023.v05i03.3115
Short DOI https://doi.org/gr9r4r
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