Molecular Aspects of Loss of Y-linked Proteins and Their Potential Applications in Cell Biology

Mohima Mitra; Rhitoban Ghosh; Madhu Parna Karmakar; Susanta Roy Karmakar; Sujit Kumar Bhowal

doi:10.36948/ijfmr.2024.v06i06.31281

Molecular Aspects of Loss of Y-linked Proteins and Their Potential Applications in Cell Biology

Author(s)	Mohima Mitra, Rhitoban Ghosh, Madhu Parna Karmakar, Susanta Roy Karmakar, Sujit Kumar Bhowal
Country	India
Abstract	Loss of proteins linked to Y chromosome (LOY) is a biomarker in human that is typically found in male blood samples. In healthy males, its frequency often rises with age. Additionally, it has lately been linked to numerous illnesses, including cancer with significantly high prevalence. A healthy male development depends on the Y chromosome and associated proteins. The deletion of this chromosome’s proteins or even its LOY variant may have effects on the male body. These proteins serve purposes beyond those of the male reproductive system. Paternity testing, ancestry research, and sexual assault investigations are just a few of the forensic situations where Y-linked protein analyses are frequently used. Due to its connection to the aging process, LOY detection has the benefit of being a biological age biomarker. The possibility of using LOY as a biomarker brings to light the need to define the molecular process underlying its occurrence and its potential applications in both health and forensic studies. Humans frequently experience LOY, a non-physiological post-zygotic molecular change that mostly affects male blood cells[Forsberg, 2017; Forsberg et al., 2017]. It is a natural part of aging and has been related to a number of illnesses, including as Alzheimer’s, Autoimmune disorders, Schizophrenia, Cardiovascular problems, and different malignancies[Holmes et al., 1985;Persanietal., 2012; Dumanskiet al., 2016; Forsberg, 2017; Forsberg et al., 2017; Haitjemaet al., 2017;]. It is possible to think about LOY as a biological age marker and a biomarker that predicts male age-related disorders [Dumanskiet al., 2016].However, LOY analysis might obstruct the forensic examination of male samples while also being helpful in forensic investigations by offering important details.
Keywords	Y-linked proteins, Biomarker, Health and forensic studies, Microdeletion, Infertility, Aging process, Haplotype, Haplogroups
Field	Biology > Zoology
Published In	Volume 6, Issue 6, November-December 2024
Published On	2024-11-30
Cite This	Molecular Aspects of Loss of Y-linked Proteins and Their Potential Applications in Cell Biology - Mohima Mitra, Rhitoban Ghosh, Madhu Parna Karmakar, Susanta Roy Karmakar, Sujit Kumar Bhowal - IJFMR Volume 6, Issue 6, November-December 2024. DOI 10.36948/ijfmr.2024.v06i06.31281
DOI	https://doi.org/10.36948/ijfmr.2024.v06i06.31281
Short DOI	https://doi.org/g8sg7f

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Molecular Aspects of Loss of Y-linked Proteins and Their Potential Applications in Cell Biology

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