Solubility Enhancement of Clozapine by Co-crystals

Author(s)	Prachi Gohil, Hitesh Jain, Satyajit Sahoo, D. B. Meshram
Country	India
Abstract	Cocrystallization of drug with coformers is a promising approach to alter the solid state properties of drug substances like solubility and dissolution. The objective of the present work was preparation, formulation and evaluation of the clozapine cocrystal by screening various coformers. Clozapine co-crystals were prepared using different coformers like benzoic acid, fumaric acid, sodium saccharin and sodium acetate. Cocrystals were prepared using solvent evaporation method and solvent drop grinding method. The prepared co-crystals were evaluated for saturation solubility, drug content, dissolution studies, XRD studies and DSC analysis.
Keywords	Clozapine, co-crystals, Sodium Saccharin, DSC, XRD
Field	Medical / Pharmacy
Published In	Volume 5, Issue 3, May-June 2023
Published On	2023-05-22
DOI	https://doi.org/10.36948/ijfmr.2023.v05i03.3158
Short DOI	https://doi.org/gr9r3z

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