International Journal For Multidisciplinary Research

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A Review on Natural Tyrosinase Inhibitors in Hyperpigmentation: Pomegranate Peel

Author(s) Suwarna Kale, Amruta Jadhav
Country India
Abstract Hyperpigmentation is a dermatological phenomenon that causes excessive melanin production, leading to skin discoloration and darkening of skin. Skin hyperpigmentation is caused by several factors, including UV exposure, oxidative stress, and inflammatory responses that enhance melanin production. Skin pigmentation is mediated by melanocytes, situated in the epidermal basal layer which synthesize eumelanin and pheomelanin, responsible for dark and light skin tones. The melanogenesis pathway involves the three essential key enzymes: tyrosinase, TYRP1, and TYRP2. Tyrosinase is a copper-containing enzyme, that facilitates melanin biosynthesis and plays key roles in skin pigmentation, healing, protection from radiation, and immune function. Tyrosinase is a critical enzyme for melanin production, and its inhibition has become a key strategy for controlling melanin synthesis. Various synthetic agents are used as tyrosinase inhibitors, but they have been linked to various dermatological issues. Phenolic-rich pomegranate peel extract is evidenced as a safe herbal-derived material promising for skin hyperpigmentation treatment. With these, it also has Anti-neoplastic, Antioxidant, Anti-microbial, and Anti-diabetic activities. Its phenolic compounds can be obtained through various extraction technologies.
Keywords Hyperpigmentation, Melanocytes, Pomegranate, Extraction and Tyrosinase
Field Medical / Pharmacy
Published In Volume 6, Issue 6, November-December 2024
Published On 2024-11-27
Cite This A Review on Natural Tyrosinase Inhibitors in Hyperpigmentation: Pomegranate Peel - Suwarna Kale, Amruta Jadhav - IJFMR Volume 6, Issue 6, November-December 2024. DOI 10.36948/ijfmr.2024.v06i06.31735
DOI https://doi.org/10.36948/ijfmr.2024.v06i06.31735
Short DOI https://doi.org/g8sdft
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