International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Next-Generation Sequencing in Haematological Diagnostics: Innovations and Clinical Applications

Author(s) Divas Srivastava
Country India
Abstract Next-generation sequencing (NGS) technologies have transformed haematological diagnostics, offering unparalleled speed, accuracy, and depth in analysing genetic variations linked to blood disorders and malignancies [1]. This review highlights the advancements and clinical applications of NGS, including its use in identifying clonal architecture, detecting minimal residual disease, and enabling personalised treatment strategies [2]. The integration of NGS into routine diagnostics has allowed for the precise identification of driver mutations, inherited blood disorders, and pharmacogenomic insights. Despite challenges such as data interpretation, assay validation, and accessibility, NGS remains a pivotal innovation in molecular diagnostics. Emerging technologies, including single-cell sequencing [3] and AI integration, promise to further revolutionise the field, ensuring that genomic insights translate into improved patient outcomes. This work underscores NGS's transformative impact on haematology, from early disease detection to the realisation of precision medicine [4].
Keywords Next-Generation Sequencing (NGS), Haematological Diagnostics, Molecular Residual Disease (MRD), Genetic Mutations, Personalised Medicine.
Field Biology > Genetics / Molecular
Published In Volume 6, Issue 6, November-December 2024
Published On 2024-12-01
Cite This Next-Generation Sequencing in Haematological Diagnostics: Innovations and Clinical Applications - Divas Srivastava - IJFMR Volume 6, Issue 6, November-December 2024. DOI 10.36948/ijfmr.2024.v06i06.32116
DOI https://doi.org/10.36948/ijfmr.2024.v06i06.32116
Short DOI https://doi.org/g8tgqn
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