International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Natural Killer Cells as Promising Candidates in Cancer Therapeutics and Related Immune Resistance in Tumor Microenvironment

Author(s) Prachi Malik
Country India
Abstract Natural killer (NK) cells, as critical components of the innate immune system, have emerged as promising candidates in cancer therapy due to their ability to recognize and destroy tumor cells without prior sensitization. Their mechanisms of action, including perforin-granzyme release and antibody-dependent cellular cytotoxicity (ADCC), position them as versatile agents in cancer immunotherapy. Recent advancements, such as chimeric antigen receptor (CAR)-NK cells and cytokine-based stimulation, have demonstrated enhanced efficacy and reduced side effects compared to conventional immunotherapies. However, the immunosuppressive tumor microenvironment (TME) remains a significant obstacle, imposing challenges like immune checkpoint activation, cytokine suppression, and metabolic constraints that impair NK cell activity. This paper explores the therapeutic potential of NK cells, the challenges of immune resistance in the TME, and emerging strategies to enhance NK cell efficacy. Addressing these challenges is crucial for optimizing NK cell-based treatments and achieving durable responses in cancer patients.
Keywords Natural killer cells, cancer therapy, tumor microenvironment, immune resistance, chimeric antigen receptor NK cells, cytokine-based therapy, immune checkpoints, immunotherapy, metabolic constraints, TGF-β.
Field Biology > Zoology
Published In Volume 6, Issue 6, November-December 2024
Published On 2024-12-07
Cite This Natural Killer Cells as Promising Candidates in Cancer Therapeutics and Related Immune Resistance in Tumor Microenvironment - Prachi Malik - IJFMR Volume 6, Issue 6, November-December 2024. DOI 10.36948/ijfmr.2024.v06i06.32510
DOI https://doi.org/10.36948/ijfmr.2024.v06i06.32510
Short DOI https://doi.org/g8t3jr
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