International Journal For Multidisciplinary Research

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Effects of Tramadol on Exploratory Behaviors, Anxiety and Memory in Balb/c Mice: 49-day Oral Dosing Study

Author(s) Lekana childerick, Miguel landry martial, Dobhat-Doukakini choupette ravelle, Abena ange Antoine
Country Congo
Abstract This study aimed to evaluate the behavioral effects of tramadol administered orally at doses of 20 mg/kg and 40 mg/kg for 49 days in BALB/c mice. Standardized behavioral tests, including the Open Field (OF), Elevated Cross Maze (ECM), Morris Water Maze (MWM), Y-maze, and Object Recognition Test (NOR), were used to measure motor activity, anxiety, and spatial and nonspatial memory. The results revealed that mice treated with the high dose of tramadol (40 mg/kg) exhibited significant reductions in motor activity, increased anxiety, and cognitive deficits in both spatial and nonspatial memory. In contrast, mice treated with 20 mg/kg tramadol exhibited increased exploratory activity during treatment, but these effects were transient. Control mice (treated with distilled water) showed no significant changes during the experiment. These results suggest that tramadol , although effective for its analgesic properties, may impair memory and increase anxiety when administered at high doses over a prolonged period. These findings highlight the importance of managing opioid side effects in a clinical and research setting.
Keywords Tramadol , motor behavior, anxiety, memory, BALB/c mice
Field Biology > Medical / Physiology
Published In Volume 6, Issue 6, November-December 2024
Published On 2024-12-14
Cite This Effects of Tramadol on Exploratory Behaviors, Anxiety and Memory in Balb/c Mice: 49-day Oral Dosing Study - Lekana childerick, Miguel landry martial, Dobhat-Doukakini choupette ravelle, Abena ange Antoine - IJFMR Volume 6, Issue 6, November-December 2024. DOI 10.36948/ijfmr.2024.v06i06.32785
DOI https://doi.org/10.36948/ijfmr.2024.v06i06.32785
Short DOI https://doi.org/g8wknz
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