International Journal For Multidisciplinary Research

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A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 7, Issue 1 (January-February 2025) Submit your research before last 3 days of February to publish your research paper in the issue of January-February.

Assessment of Corticosteroid Use In Tertiary Care Hospital

Author(s) Hinda Mazhar MP, Nisar Ahmed, Abul Kalam Azad, Deeksha S, Shamim Akhtar Hussain
Country India
Abstract Corticosteroids - synthetic analogues of natural adrenal cortex hormones are widely used to treat various conditions. However, their long-term use can lead to risks. To assess the use of Corticosteroids in order to understand their benefits and risks, a prospective, observational study was conducted which analyzed corticosteroid use among 56 patients, 3.5% being infants, 8.9% being children, adults and older adults comprising 44.6% and 42.8% respectively, among which there were 20 males (36%) and 36 females (64%). A total of 92 corticosteroids were prescribed: 42 (45.6%) Dexamethasone, 9 (9.7%) Hydrocortisone, 12 (13%) Prednisolone, 27 (29.3%) Budesonide, 1 (1%) Beclomethasone, and 1 (1%) Fluticasone. Administration routes included oral (15, 16.3%), intravenous (48, 52.1%), and inhalation (29, 31.5%). The most common conditions treated included bronchitis (19.6%), pneumonia (17.8%), and COPD (14.2%). Adverse drug reactions (ADRs) occurred in 23 patients (41%), with common ADRs being hyperglycemia (29%), post-injection flare (32.2%), and hoarseness (16.1%), followed by osteoporosis, and least being hypertension, Cushing’s syndrome, facial puffiness, electrolyte imbalance, GI disturbances. Dexamethasone was associated with ADRs in 13 patients (56.5%), Budesonide in 8 (34.7%), Prednisolone in 3 (4.3%), Hydrocortisone, Beclomethasone, Fluticasone in 1 patient each. Interactions were observed in 42 patients (75%), mainly between corticosteroids and other drugs (57.3%), 1.4% with food, and 41.1% with co-morbidities. Minor interactions occurred in 38 patients (55.8%) and moderate in 30 (44.1%). Significant associations (p < 0.05) were found in the short-term use between hyperglycemia and hoarseness. This underscores the need for vigilant monitoring of side effects during therapy.
Keywords Corticosteroids, Adverse Drug Reactions, Drug-Interactions, Indications
Field Medical / Pharmacy
Published In Volume 7, Issue 1, January-February 2025
Published On 2025-01-16
Cite This Assessment of Corticosteroid Use In Tertiary Care Hospital - Hinda Mazhar MP, Nisar Ahmed, Abul Kalam Azad, Deeksha S, Shamim Akhtar Hussain - IJFMR Volume 7, Issue 1, January-February 2025. DOI 10.36948/ijfmr.2025.v07i01.33317
DOI https://doi.org/10.36948/ijfmr.2025.v07i01.33317
Short DOI https://doi.org/g82hkv

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