Pituitary Stem Interruption Syndrome and Celiac Disease: when endocrinopathy and autoimmunity meet

Author(s)	Akki Hajar, Abourzzak Sana, Chaouki Sana, Idrissi Mounia, M. Boubou, M. Hida
Country	Morocco
Abstract	Pituitary stem interruption syndrome (PSI) is a rare and severe congenital anomaly characterized by pituitary insufficiency of structural origin. Clinically, SITP often manifests itself in childhood as an isolated statural growth retardation associated with growth hormone deficiency, but may also involve other hormonal deficiencies, depending on the severity of the involvement. Furthermore, recent studies suggest an interconnection between SITP and certain autoimmune diseases, such as celiac disease, an autoimmune enteropathy triggered by gluten. This association, although rare, illustrates the complex interactions between the endocrine and immune axes, underlining the importance of multidisciplinary clinical exploration in the diagnosis and management of patients. This article provides an in-depth analysis of this association, focusing on its diagnosis, therapeutic implications, and potential relationship with other autoimmune conditions.
Keywords	Key words: Pituitary stem interruption syndrome (PSI), Statural delay, Celiac disease, Autoimmune diseases
Field	Medical / Pharmacy
Published In	Volume 6, Issue 6, November-December 2024
Published On	2024-12-29
DOI	https://doi.org/10.36948/ijfmr.2024.v06i06.34182
Short DOI	https://doi.org/g8xgm2

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International Journal For Multidisciplinary Research