International Journal For Multidisciplinary Research

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Evaluating the efficacy of phytochemicals in treating urolithiasis by inhibiting the mechanism of action in the pathophysiology of stone formation.

Author(s) Kashish Parvani, Harsh Vardhan Katariya, Ashok Thalkar, Rehanabanu Darvadiya
Country India
Abstract This article discussed pathophysiology, investigation, and management on recurrent kidney stone disease, The aforementioned study pertains to treatment in urolithiasis or Nephrolithiasis which refers to the condition characterized by hard mineral structures formed in the urinary tract. Urolithiasis is increasingly addressing the use of phytochemicals in treatment options because of the natural origin and minimum side effects of their interventions. The pathophysiology of urolithiasis or Nephrolithiasis encompasses: supersaturation, nucleation, crystal aggregation, growth, which interaction with epithelial cells, leading to Urolithiasis. Phytochemical of mention herbal its commonly bioactive compounds such as Saponin, flavonoids, alkaloids & glycosides, possess diuretic antioxidant, & anti-inflammatory, effects that act effectively inhibit the urolithiasis or Nephrolithiasis mechanisms.

Studies revealed that phytochemicals inhibition of supersaturation by altering urinary pH and increasing solubility of minerals forming stones. All these phytochemicals protect & treat the renal epithelial cells from oxidative stress and inflammatory responses instigated by crystal-cell interactions, further hampering the progression of stones in addition to damage to the tissue. Extracts from plants such as PHYLLANTHUS NIRURI, SYZYGIUM CUMINI, URTICA DIOICA.L, HIBISCUS SABDARIFFA, have been researched widely, showing positive results for promoting dissolution and preventing recurrence of the crystals stone.

This review will put forward the efficacy of the phytochemicals as a therapeutic approach to urolithiasis & nephrolithiasis focusing on their role targeting important inhibition of stone formation.
Keywords Phytochemicals, herbal bioactive compounds, Diuretic, antioxidant, anti-inflammatory, Prevention of recurrence, dissolution of stones, protection of renal epithelial cells, Therapeutic efficacy of phytochemicals in targeting, inhibiting stone formation, Saponins, flavonoids, alkaloids, glycosides,tannins.
Field Medical / Pharmacy
Published In Volume 7, Issue 1, January-February 2025
Published On 2025-01-07
Cite This Evaluating the efficacy of phytochemicals in treating urolithiasis by inhibiting the mechanism of action in the pathophysiology of stone formation. - Kashish Parvani, Harsh Vardhan Katariya, Ashok Thalkar, Rehanabanu Darvadiya - IJFMR Volume 7, Issue 1, January-February 2025. DOI 10.36948/ijfmr.2025.v07i01.34731
DOI https://doi.org/10.36948/ijfmr.2025.v07i01.34731
Short DOI https://doi.org/g82hds
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