International Journal For Multidisciplinary Research

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A Comprehensive Review of Solid Lipid Nanoparticles

Author(s) Arunodaya B S, Prakash S Goudanavar, N. Raghavendra Naveen
Country India
Abstract Liposomes, polymeric nanoparticles, and emulsions are alternatives to other popular colloidal carriers. Because of its advantages, solid lipid nanoparticles were developed in the early 1990s, including controlled drug release, focused drug delivery, and outstanding durability. The many methods utilized to manufacture solid lipid nanoparticles and excipients, including the membrane contractor technique, are summarised in this article, along with their possible benefits and drawbacks. Solid lipid nanoparticle (SLN) stability relies on maintaining particle size, drug encapsulation, and integrity over time. Excipients like surfactants and lipids influence stability, preventing aggregation and oxidation. Drying techniques, such as spray drying and lyophilization, enhance stability by converting SLNs to solid forms, while lipid composition and drug-lipid compatibility are crucial factors. So, the instrumental techniques employed and the difficulties associated with SLN manufacturing are thoroughly examined. Particular focus is placed on the SLN release pattern and drug integration models in SLN. The main uses of SLNs, including targeted drug delivery, and the analytical approaches used in SLN assessments, are covered in detail. The main objective of this work is a thorough overview of solid lipid nanoparticles, including production methods, characterization, and routes of administration. A discussion of the components of the SLN delivery mechanism and the in vivo destiny of the carriers are also included.
Keywords Solid lipid nanoparticles, solid lipid, surfactants, colloidal drug carriers, and drug incorporation.
Field Medical / Pharmacy
Published In Volume 7, Issue 1, January-February 2025
Published On 2025-01-19
Cite This A Comprehensive Review of Solid Lipid Nanoparticles - Arunodaya B S, Prakash S Goudanavar, N. Raghavendra Naveen - IJFMR Volume 7, Issue 1, January-February 2025. DOI 10.36948/ijfmr.2025.v07i01.34937
DOI https://doi.org/10.36948/ijfmr.2025.v07i01.34937
Short DOI https://doi.org/g82gt7

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