International Journal For Multidisciplinary Research

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Study of CTX-M Types ESBLs Produced by Enterobacteriaceae Collected from Clinical Isolates

Author(s) Dr. Krishna Kumar Patel, Dr.Sarita Patel, Dr. Saradia Kar
Country India
Abstract The extended-spectrum β-lactamases (ESBLs) have been reported in various clinical isolates obtained from hospitals in India, however, there is no data on the prevalence and antibiotic susceptibility patterns of CTX-M type ESBL produced by Gram-negative bacilli. The aim of this study was to determine the frequency and distribution of the blaCTX-M genes and the susceptibility patterns in ESBL producing clinical isolates of Gram-negative bacilli. A total of 200 non-duplicate and pure isolates obtained from clinical isolates and identification of the isolates was performed by MALDI-TOF mass spectrometry. Susceptibility testing and ESBL detection was performed using VITEK® 2, according to EUCAST v4.0 guidelines. Genotypic analysis was performed using Check-MDR CT103 Microarrays. Out of total 112 isolates screen positive for ESBLs, 71 tested positive for ESBL encoding genes by Check-MDR array. Among the CTX-M types, blaCTX-M carrying Enterobacteriaceae (n = 64) isolates showed no resistance against imipenem and meropenem and a moderate resistance rate against tigecycline, fosfomycin and amikacin. On the other hand, all the blaCTX-M positive Enterobacteriaceae showed a multidrug resistant (MDR) phenotype with remarkable co-resistances (non-susceptibility rates) to aminoglycosides, fluoroquinolones and trimethoprim/sulfamethoxazol. This study demonstrates a remarkably high prevalence of blaCTX-M genes among ESBL-producing isolates. The high level of resistance to β-lactam and non-β-lactam antibiotics as well as the trend to a MDR profile associated with the blaCTX-M genes are alarming and poses the requirement for appropriate choice of antimicrobial therapy.
Keywords Keywords: Enterobacteriaceae, Extended spectrum beta lactamase, CTX-M, antibiotic resistance
Field Biology > Medical / Physiology
Published In Volume 7, Issue 1, January-February 2025
Published On 2025-01-18
Cite This Study of CTX-M Types ESBLs Produced by Enterobacteriaceae Collected from Clinical Isolates - Dr. Krishna Kumar Patel, Dr.Sarita Patel, Dr. Saradia Kar - IJFMR Volume 7, Issue 1, January-February 2025. DOI 10.36948/ijfmr.2025.v07i01.35062
DOI https://doi.org/10.36948/ijfmr.2025.v07i01.35062
Short DOI https://doi.org/g82gsn
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