International Journal For Multidisciplinary Research

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Gestational Pemphigoid: A Comprehensive Review of Clinical Features, Differential Diagnosis, and Management Strategies with Case Report

Author(s) Guelzim Khalid, Hamza Messaoudi, Benlghazi Abdelhamid, Benali Saad, Rachid Ait Bouhou, Fatima Elmangoub, Moulay Mehdi El Hassani, Jaouad Kouach
Country Morocco
Abstract Gestational pemphigoid (GP) is a rare autoimmune blistering disorder that typically occurs in the second or third trimester of pregnancy. Characterized by pruritic, tense blisters primarily affecting the abdomen and extremities, GP can lead to significant discomfort and potential complications for both the mother and fetus. The condition is caused by the production of autoantibodies against basement membrane proteins, resulting in subepithelial blister formation. Differential diagnoses include other pregnancy-related dermatoses, such as pruritic urticarial papules and plaques of pregnancy (PUPPP) and drug-induced bullous eruptions. Histopathological findings typically reveal subepidermal vesicles and lympho-eosinophilic infiltrates, although direct immunofluorescence may be negative in some cases. Management primarily involves symptomatic treatment with corticosteroids and antihistamines, leading to favorable outcomes for most patients. This review highlights the clinical features, differential diagnoses, and management strategies for gestational pemphigoid, emphasizing the importance of early recognition and intervention to ensure maternal and fetal health
Keywords Gestational Pemphigoid,Autoimmune Blistering Disorder,Pregnancy Dermatoses,Subepithelial Blisters,Differential Diagnosis,Corticosteroids
Field Medical / Pharmacy
Published In Volume 7, Issue 1, January-February 2025
Published On 2025-01-23
Cite This Gestational Pemphigoid: A Comprehensive Review of Clinical Features, Differential Diagnosis, and Management Strategies with Case Report - Guelzim Khalid, Hamza Messaoudi, Benlghazi Abdelhamid, Benali Saad, Rachid Ait Bouhou, Fatima Elmangoub, Moulay Mehdi El Hassani, Jaouad Kouach - IJFMR Volume 7, Issue 1, January-February 2025. DOI 10.36948/ijfmr.2025.v07i01.35658
DOI https://doi.org/10.36948/ijfmr.2025.v07i01.35658
Short DOI https://doi.org/g82wnw
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